Tranexil
Generic Name
Tranexamic Acid
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tranexil 500 mg injection | ৳ 50.00 | N/A |
Description
Overview of the medicine
Tranexamic acid is an antifibrinolytic agent used to prevent or reduce excessive bleeding in various medical and surgical conditions.
Uses & Indications
Dosage
Adults
For local fibrinolysis: 500 mg (1 ampoule) by slow intravenous injection 2 to 3 times daily. For general fibrinolysis: 1 g (2 ampoules) by slow intravenous injection 3 times daily. Doses should be adjusted based on the specific indication and patient condition.
Elderly
No specific dose reduction required unless there is renal impairment.
Renal_impairment
Dose reduction is necessary based on creatinine clearance. For CrCl 30-60 mL/min: 10 mg/kg twice daily. For CrCl 10-30 mL/min: 10 mg/kg daily. For CrCl < 10 mL/min: 5 mg/kg daily.
How to Take
Administered by slow intravenous injection or infusion. Must not be given intramuscularly.
Mechanism of Action
Tranexamic acid inhibits fibrinolysis by reversibly blocking the lysine binding sites on plasminogen, thereby preventing plasmin from binding to and degrading fibrin.
Pharmacokinetics
Onset
Within minutes after IV administration.
Excretion
Mainly via renal excretion (glomerular filtration) within 24 hours.
Half life
Approximately 2-3 hours.
Absorption
Rapidly absorbed after intravenous administration, reaching peak plasma concentration within minutes.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- •Active intravascular clotting (e.g., DVT, pulmonary embolism)
- •Severe renal impairment (risk of accumulation)
- •History of convulsions
- •Subarachnoid hemorrhage (risk of cerebral edema and infarction)
- •Hypersensitivity to tranexamic acid
Drug Interactions
Thrombolytic agents
Antagonistic effects.
Combined oral contraceptives/Estrogens
Increased risk of thromboembolism.
Anticoagulants (e.g., Warfarin, Heparin)
Concurrent use should be avoided as tranexamic acid reverses the anticoagulant effects.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms may include nausea, vomiting, diarrhea, dizziness, headache, hypotension. Management is supportive and symptomatic, including fluid and electrolyte replacement. Hemodialysis may be considered in severe renal impairment.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk in small amounts; generally considered safe for breastfeeding, but caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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