Trapic
Generic Name
Tranexamic Acid
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trapic 500 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Trapic (Tranexamic Acid) is an antifibrinolytic agent used to prevent and treat various types of bleeding. It works by inhibiting the breakdown of blood clots, thus promoting hemostasis.
Uses & Indications
Dosage
Adults
Oral: 1-1.5 g (2-3 tablets of 500 mg) two to three times daily. IV: 10 mg/kg three to four times daily. Dosing varies significantly by indication and route.
Elderly
Generally, no specific dose adjustment needed unless renal impairment is present. Start with lower doses.
Renal_impairment
Dose adjustment required based on creatinine clearance. For severe impairment, not recommended.
How to Take
Tablets can be taken with or without food. Injections are administered slowly intravenously.
Mechanism of Action
Tranexamic acid competitively inhibits the activation of plasminogen to plasmin, thereby preventing the dissolution of fibrin clots. It binds to the lysine binding sites on plasminogen and plasmin, thus blocking their interaction with fibrin.
Pharmacokinetics
Onset
Oral: 1-2 hours; Intravenous: Rapid.
Excretion
Primarily excreted unchanged in the urine, mainly by glomerular filtration, within 24 hours.
Half life
Approximately 2-11 hours (dose and renal function dependent).
Absorption
Rapidly absorbed after oral administration, with bioavailability around 30-50%. Peak plasma concentration is reached within 3 hours.
Metabolism
Minimally metabolized; less than 5% of the dose is metabolized.
Side Effects
Contraindications
- Active intravascular clotting
- Severe renal impairment
- History of thrombosis or thromboembolic disease
- Subarachnoid hemorrhage (risk of cerebral edema and infarction)
- Hypersensitivity to tranexamic acid
Drug Interactions
Combined hormonal contraceptives
Increased risk of thrombosis.
Factor IX complex concentrates or anti-inhibitor coagulant complexes
Increased risk of thrombosis.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, orthostatic hypotension, dizziness, headache, and visual disturbances. Management is supportive, including gastric lavage or induced emesis, and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm, but human data is limited. Use only if clearly needed. Excreted in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Active intravascular clotting
- Severe renal impairment
- History of thrombosis or thromboembolic disease
- Subarachnoid hemorrhage (risk of cerebral edema and infarction)
- Hypersensitivity to tranexamic acid
Drug Interactions
Combined hormonal contraceptives
Increased risk of thrombosis.
Factor IX complex concentrates or anti-inhibitor coagulant complexes
Increased risk of thrombosis.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, orthostatic hypotension, dizziness, headache, and visual disturbances. Management is supportive, including gastric lavage or induced emesis, and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm, but human data is limited. Use only if clearly needed. Excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Widely approved globally
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Tranexamic acid has been extensively studied in various clinical trials for its efficacy in managing different types of bleeding, including menstrual, surgical, and traumatic hemorrhages.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, creatinine clearance) in patients with renal impairment.
- Coagulation parameters (e.g., PT, PTT) for prolonged use or high-risk patients.
Doctor Notes
- Always consider patient's thrombotic risk factors before prescribing.
- Adjust dose in renal impairment. Monitor for visual disturbances if used long-term.
- Avoid concomitant use with combined hormonal contraceptives.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Report any unusual bleeding, bruising, or signs of clotting immediately.
- Do not stop taking the medicine without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness or visual disturbances in some patients. If you experience these symptoms, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid activities that may increase the risk of injury or bleeding.
- Discuss any changes in your health or other medications with your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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