Tribion
Generic Name
Thiamine Mononitrate + Pyridoxine Hydrochloride + Cyanocobalamin
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tribion 100 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Tribion 100 mg Tablet is a combination of B vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) used to treat or prevent vitamin B deficiencies, and associated neurological and metabolic disorders. It supports nerve health, energy production, and red blood cell formation.
Uses & Indications
Dosage
Adults
Typically 1-2 tablets daily, or as directed by physician.
Elderly
No specific dosage adjustment needed, but caution with very high doses in renal impairment.
Renal_impairment
No specific adjustment for mild to moderate impairment. Consult physician for severe renal disease due to potential accumulation of pyridoxine.
How to Take
Oral administration, usually with or after meals. Swallow whole with water.
Mechanism of Action
Thiamine (B1) acts as a coenzyme in carbohydrate metabolism. Pyridoxine (B6) is involved in amino acid metabolism, neurotransmitter synthesis, and heme synthesis. Cyanocobalamin (B12) is essential for DNA synthesis, myelin formation, and red blood cell maturation.
Pharmacokinetics
Onset
Effects on symptoms like fatigue or neuropathic pain may be noticed within days to weeks.
Excretion
Primarily renal (urine) for thiamine and pyridoxine metabolites. B12 excreted via bile and urine, with significant enterohepatic recirculation.
Half life
Thiamine: 90-180 minutes (in plasma), Pyridoxine: 15-20 days (active form), Cyanocobalamin: variable, stored in liver.
Absorption
Readily absorbed from the gastrointestinal tract, especially thiamine and pyridoxine. B12 absorption requires intrinsic factor.
Metabolism
Thiamine is metabolized in the liver. Pyridoxine is converted to its active form, pyridoxal 5-phosphate. Cyanocobalamin undergoes minimal metabolism.
Side Effects
Contraindications
- Hypersensitivity to any of the active ingredients or excipients
- Leber's disease (due to B12, as it may cause optic nerve atrophy)
Drug Interactions
Levodopa
Pyridoxine (B6) can decrease the effectiveness of levodopa (used in Parkinson's disease) if taken without a peripheral decarboxylase inhibitor.
Isoniazid, Metformin
Isoniazid can interfere with pyridoxine metabolism; Metformin may reduce B12 absorption.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include gastrointestinal upset, skin reactions, and in very high doses of pyridoxine, sensory neuropathy (rare and reversible upon discontinuation).
Pregnancy & Lactation
Generally considered safe at recommended doses, but always consult a doctor. Excessive doses of pyridoxine may be harmful. B vitamins are excreted in breast milk, but usually within safe limits.
Side Effects
Contraindications
- Hypersensitivity to any of the active ingredients or excipients
- Leber's disease (due to B12, as it may cause optic nerve atrophy)
Drug Interactions
Levodopa
Pyridoxine (B6) can decrease the effectiveness of levodopa (used in Parkinson's disease) if taken without a peripheral decarboxylase inhibitor.
Isoniazid, Metformin
Isoniazid can interfere with pyridoxine metabolism; Metformin may reduce B12 absorption.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include gastrointestinal upset, skin reactions, and in very high doses of pyridoxine, sensory neuropathy (rare and reversible upon discontinuation).
Pregnancy & Lactation
Generally considered safe at recommended doses, but always consult a doctor. Excessive doses of pyridoxine may be harmful. B vitamins are excreted in breast milk, but usually within safe limits.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved by national health authorities (e.g., DGDA in Bangladesh)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials support the efficacy of B vitamins in treating deficiencies and related neuropathies. Specific trials for 'Tribion' brand would depend on the manufacturer's research.
Lab Monitoring
- No routine lab monitoring is generally required for vitamin B complex supplementation unless specific deficiency is being treated or in cases of suspected overdose.
Doctor Notes
- Advise patients to report any unusual neurological symptoms.
- Consider underlying causes of vitamin deficiency.
- Monitor for therapeutic response in neuropathic conditions.
Patient Guidelines
- Take as directed by your doctor or pharmacist.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Store in a cool, dry place away from direct sunlight.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Tribion 100 mg Tablet is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in B vitamins.
- Avoid excessive alcohol consumption, which can deplete B vitamins.
- Regular exercise can improve overall health and aid in recovery from certain conditions.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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