Tridol
Generic Name
Tramadol Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tridol 100 mg injection | ৳ 20.00 | N/A |
Description
Overview of the medicine
Tridol 100 mg Injection contains Tramadol Hydrochloride, a synthetic opioid analgesic. It is used for the management of moderate to moderately severe pain.
Uses & Indications
Dosage
Adults
Initial dose 50-100 mg IV or IM slowly every 4-6 hours as needed. Maximum daily dose usually 400 mg.
Elderly
For patients over 75 years, maximum daily dose should not exceed 300 mg.
Renal_impairment
Reduce total daily dose and/or extend dosing interval (e.g., 50-100 mg every 12 hours) for creatinine clearance <30 mL/min.
How to Take
Tridol 100 mg Injection should be administered slowly by intravenous infusion (over 2-3 minutes) or as a deep intramuscular injection. For IV infusion, it may be diluted with suitable solutions.
Mechanism of Action
Tramadol works by binding to mu-opioid receptors in the central nervous system. It also inhibits the reuptake of norepinephrine and serotonin, which contributes to its analgesic effect.
Pharmacokinetics
Onset
IV: 5-10 minutes; IM: 15-30 minutes.
Excretion
Primarily excreted by the kidneys (approximately 80% as metabolites and unchanged drug).
Half life
Approximately 6.3 hours (unmetabolized tramadol), 7.9 hours (active metabolite O-desmethyltramadol).
Absorption
Rapid and complete absorption after intramuscular (IM) or intravenous (IV) administration. Bioavailability is approximately 100% after IV administration.
Metabolism
Extensively metabolized in the liver by CYP2D6 and CYP3A4 enzymes to O-desmethyltramadol (active) and other inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to tramadol or any component of the injection
- Acute intoxication with alcohol, hypnotics, opioid analgesics, or psychotropic drugs
- Epilepsy not controlled by treatment
- Concomitant use with MAO inhibitors or within 14 days of stopping them
Drug Interactions
Warfarin
Increased INR and risk of bleeding.
Carbamazepine
Significantly reduces tramadol plasma levels and analgesic effect.
MAO Inhibitors
Risk of serotonin syndrome and seizures.
SSRIs, SNRIs, TCAs
Increased risk of serotonin syndrome and seizures.
CNS Depressants (e.g., benzodiazepines, other opioids, alcohol)
Increased risk of profound sedation, respiratory depression, coma, and death.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include respiratory depression, somnolence, coma, seizures, miosis, cardiovascular collapse, and death. Management includes maintaining a patent airway, providing ventilatory support, and administering naloxone to reverse respiratory depression.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy, especially in the third trimester, due to risk of neonatal opioid withdrawal syndrome. Excreted into breast milk; not recommended during lactation.
Side Effects
Contraindications
- Hypersensitivity to tramadol or any component of the injection
- Acute intoxication with alcohol, hypnotics, opioid analgesics, or psychotropic drugs
- Epilepsy not controlled by treatment
- Concomitant use with MAO inhibitors or within 14 days of stopping them
Drug Interactions
Warfarin
Increased INR and risk of bleeding.
Carbamazepine
Significantly reduces tramadol plasma levels and analgesic effect.
MAO Inhibitors
Risk of serotonin syndrome and seizures.
SSRIs, SNRIs, TCAs
Increased risk of serotonin syndrome and seizures.
CNS Depressants (e.g., benzodiazepines, other opioids, alcohol)
Increased risk of profound sedation, respiratory depression, coma, and death.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include respiratory depression, somnolence, coma, seizures, miosis, cardiovascular collapse, and death. Management includes maintaining a patent airway, providing ventilatory support, and administering naloxone to reverse respiratory depression.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy, especially in the third trimester, due to risk of neonatal opioid withdrawal syndrome. Excreted into breast milk; not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored correctly.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Tramadol has undergone extensive clinical trials demonstrating its efficacy and safety for various types of pain, including post-surgical and chronic pain. Studies have evaluated its pharmacokinetic profile and potential drug interactions.
Lab Monitoring
- Monitor renal and hepatic function, especially during long-term therapy or in patients with pre-existing impairment.
Doctor Notes
- Assess patient's risk for opioid addiction, abuse, and misuse prior to prescribing and periodically during therapy.
- Monitor for signs of respiratory depression, especially during initiation of therapy or after a dose increase, and with concomitant use of other CNS depressants.
- Educate patients and caregivers about the risks of respiratory depression and overdose.
Patient Guidelines
- Do not stop the medication abruptly without consulting your doctor, as withdrawal symptoms may occur.
- Avoid activities requiring mental alertness, such as driving or operating machinery, until you know how Tridol affects you.
- Report any severe side effects, especially difficulty breathing or seizures, to your doctor immediately.
Missed Dose Advice
If a dose is missed, administer it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double dose to make up for a missed one. Contact your doctor for advice.
Driving Precautions
Tridol 100 mg Injection may cause dizziness, drowsiness, or blurred vision. Do not drive or operate heavy machinery until you know how this medication affects your ability to perform such tasks safely.
Lifestyle Advice
- Maintain adequate hydration to help manage constipation.
- Discuss any concerns about addiction or dependence with your healthcare provider.
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