Trigent
Generic Name
Trimetazidine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trigent 200 mg capsule | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Trigent (Trimetazidine) is a cytoprotective anti-ischemic agent used for the symptomatic treatment of stable angina pectoris. It helps to improve myocardial energy metabolism and reduces the frequency of angina attacks.
Uses & Indications
Dosage
Adults
One 35 mg MR tablet twice daily (morning and evening) during meals.
Elderly
Same as adult dose, but caution is advised in patients with moderate renal impairment. Dose adjustment may be needed.
Renal_impairment
In moderate renal impairment (creatinine clearance 30-60 mL/min), one 35 mg MR tablet daily in the morning.
How to Take
Oral administration. Tablets should be taken with meals, swallowed whole with water, not chewed or crushed.
Mechanism of Action
Trimetazidine inhibits beta-oxidation of fatty acids by blocking long-chain 3-ketoacyl CoA thiolase, which shifts myocardial energy production from fatty acid oxidation to glucose oxidation. This helps to maintain cellular energy levels during ischemia.
Pharmacokinetics
Onset
Within a few hours for acute effects, chronic benefits accrue over days to weeks.
Excretion
Mainly through urine as unchanged drug.
Half life
Approximately 4-6 hours (for immediate release), 7-10 hours (for modified release).
Absorption
Rapidly absorbed after oral administration, peak plasma concentration reached within 2 hours.
Metabolism
Not extensively metabolized, primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Trimetazidine or any excipients
- Parkinson's disease, parkinsonian symptoms, tremors, restless leg syndrome and other related movement disorders
- Severe renal impairment (creatinine clearance < 30 mL/min)
Drug Interactions
No clinically significant drug interactions have been reported.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited data on overdose. Symptomatic treatment and supportive measures should be initiated. Gastric lavage may be considered.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to insufficient data. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Trimetazidine or any excipients
- Parkinson's disease, parkinsonian symptoms, tremors, restless leg syndrome and other related movement disorders
- Severe renal impairment (creatinine clearance < 30 mL/min)
Drug Interactions
No clinically significant drug interactions have been reported.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited data on overdose. Symptomatic treatment and supportive measures should be initiated. Gastric lavage may be considered.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to insufficient data. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available, original patent expired
Clinical Trials
Extensive clinical trials have demonstrated efficacy in reducing angina frequency and improving exercise tolerance. Studies also support its use in other vascular-related conditions.
Lab Monitoring
- No routine lab monitoring is generally required. Monitor renal function in patients with impairment.
Doctor Notes
- Patients should be informed about the risk of dizziness and advised not to drive if affected.
- Not for acute angina attacks, but for chronic management.
Patient Guidelines
- Take regularly as prescribed.
- Do not stop taking without consulting your doctor.
- Report any new or worsening symptoms.
Missed Dose Advice
If a dose is missed, take the next dose at the usual time. Do not double the dose to compensate for a missed one.
Driving Precautions
May cause dizziness or somnolence; exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and regular exercise. Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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