Triject
Generic Name
Ceftriaxone
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| triject 500 mg injection | ৳ 180.00 | N/A |
Description
Overview of the medicine
Ceftriaxone is a broad-spectrum cephalosporin antibiotic used to treat a wide range of bacterial infections, including serious ones.
Uses & Indications
Dosage
Adults
Typically 1-2 grams IV/IM once daily or in two divided doses. For 500mg strength, 500mg to 1g daily for milder infections. Max 4 grams/day.
Elderly
Same as adults, but caution should be exercised in patients with significant renal or hepatic impairment.
Renal_impairment
Dosage adjustment may be necessary in severe renal impairment, especially with concomitant hepatic impairment.
How to Take
Administered by intramuscular (IM) or intravenous (IV) injection. IV administration should be slow (over 2-4 minutes).
Mechanism of Action
Ceftriaxone works by inhibiting the bacterial cell wall synthesis, leading to bacterial cell death.
Pharmacokinetics
Onset
Rapid onset of action after intravenous administration.
Excretion
Excreted via both renal (kidney) and biliary (liver/bile) routes.
Half life
Approximately 6 to 9 hours.
Absorption
Rapid and complete absorption after intramuscular (IM) or intravenous (IV) administration.
Metabolism
Primarily not metabolized; small amount undergoes hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to ceftriaxone, any other cephalosporin, or penicillins
- Neonates with hyperbilirubinemia, especially premature neonates
Drug Interactions
Loop diuretics
Increased risk of nephrotoxicity.
Aminoglycosides
May have synergistic effects, but renal function should be monitored.
Oral anticoagulants
May increase the risk of bleeding.
Calcium-containing solutions
Concomitant use with calcium-containing solutions is contraindicated in neonates and not recommended in other age groups.
Storage
Store below 30°C. Protect from light and moisture. The reconstituted solution has limited stability and should be used promptly.
Overdose
In case of overdose, symptomatic and supportive treatment should be given. Hemodialysis and peritoneal dialysis are not effective for removing ceftriaxone.
Pregnancy & Lactation
Pregnancy Category B. Excreted in breast milk in small amounts; use with caution in lactating mothers.
Side Effects
Contraindications
- Hypersensitivity to ceftriaxone, any other cephalosporin, or penicillins
- Neonates with hyperbilirubinemia, especially premature neonates
Drug Interactions
Loop diuretics
Increased risk of nephrotoxicity.
Aminoglycosides
May have synergistic effects, but renal function should be monitored.
Oral anticoagulants
May increase the risk of bleeding.
Calcium-containing solutions
Concomitant use with calcium-containing solutions is contraindicated in neonates and not recommended in other age groups.
Storage
Store below 30°C. Protect from light and moisture. The reconstituted solution has limited stability and should be used promptly.
Overdose
In case of overdose, symptomatic and supportive treatment should be given. Hemodialysis and peritoneal dialysis are not effective for removing ceftriaxone.
Pregnancy & Lactation
Pregnancy Category B. Excreted in breast milk in small amounts; use with caution in lactating mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture. Refer to the packaging for exact expiry.
Availability
Hospitals, Pharmacies
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Ceftriaxone has undergone extensive clinical trials and studies since its introduction, demonstrating its efficacy and safety profile across various bacterial infections.
Lab Monitoring
- Renal function tests
- Liver function tests
- Complete Blood Count (CBC)
Doctor Notes
- A commonly used broad-spectrum antibiotic for empiric therapy.
- Important for severe community-acquired and hospital-acquired infections.
- Exercise caution in neonates due to interaction with calcium-containing solutions.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Report any severe diarrhea or allergic reactions to your doctor immediately.
- Do not share this medicine with others.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is close to the time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Generally safe, but some patients may experience dizziness. If dizziness occurs, avoid driving or operating machinery.
Lifestyle Advice
- Stay well-hydrated during the treatment course.
- Avoid alcohol if feeling unwell or experiencing gastrointestinal side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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