Trilock
Generic Name
Atorvastatin
Manufacturer
Intas Pharmaceuticals Ltd.
Country
India
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trilock 10 mg tablet | ৳ 17.00 | ৳ 238.00 |
Description
Overview of the medicine
Trilock 10 mg Tablet contains Atorvastatin, a medication used to lower high cholesterol levels and reduce the risk of heart disease, stroke, and other cardiovascular problems. It belongs to a group of medicines called statins.
Uses & Indications
Dosage
Adults
Initial dose is usually 10 mg once daily. The dose can be adjusted by a doctor based on LDL-C goals and patient response, up to a maximum of 80 mg daily.
Elderly
No specific dose adjustment is required based on age. Follow adult dosage recommendations.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
How to Take
Take Trilock 10 mg Tablet orally once daily, with or without food, at any time of the day. It is usually taken at the same time each day for consistency.
Mechanism of Action
Atorvastatin works by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol production in the liver. This reduces the amount of cholesterol the body makes, particularly LDL (bad) cholesterol, and increases the liver's ability to remove LDL cholesterol from the blood.
Pharmacokinetics
Onset
Significant lipid-lowering effects typically observed within 2 weeks, with maximal response usually achieved by 4 weeks.
Excretion
Primarily excreted in the bile following hepatic and/or extrahepatic metabolism. Less than 2% is recovered in the urine.
Half life
Approximately 14 hours (for parent drug and active metabolites), but inhibition of HMG-CoA reductase activity persists for 20-30 hours due to active metabolites.
Absorption
Rapidly absorbed from the gastrointestinal tract; absolute bioavailability is approximately 12%. Peak plasma concentrations achieved within 1 to 2 hours.
Metabolism
Extensively metabolized by cytochrome P450 3A4 (CYP3A4) in the liver to active ortho- and parahydroxylated metabolites and various beta-oxidation products.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases
- Pregnancy and lactation
- Hypersensitivity to Atorvastatin or any component of the formulation
Drug Interactions
Warfarin
Potentiation of anticoagulant effect, requiring careful INR monitoring.
Gemfibrozil and other fibrates
Increased risk of myopathy when co-administered.
Clarithromycin, Erythromycin, Itraconazole
Increased plasma concentrations of atorvastatin, increasing risk of side effects.
Cyclosporine, Telaprevir, Ritonavir/Lopinavir
Increased risk of myopathy/rhabdomyolysis due to significantly increased atorvastatin exposure.
Storage
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for atorvastatin overdose. In case of an overdose, symptomatic and supportive measures should be initiated as necessary. Liver function tests and CK levels should be monitored.
Pregnancy & Lactation
Atorvastatin is contraindicated during pregnancy (Pregnancy Category X) due to the potential for fetal harm. It is also contraindicated in breastfeeding mothers as it may pass into breast milk and cause adverse effects in the infant.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases
- Pregnancy and lactation
- Hypersensitivity to Atorvastatin or any component of the formulation
Drug Interactions
Warfarin
Potentiation of anticoagulant effect, requiring careful INR monitoring.
Gemfibrozil and other fibrates
Increased risk of myopathy when co-administered.
Clarithromycin, Erythromycin, Itraconazole
Increased plasma concentrations of atorvastatin, increasing risk of side effects.
Cyclosporine, Telaprevir, Ritonavir/Lopinavir
Increased risk of myopathy/rhabdomyolysis due to significantly increased atorvastatin exposure.
Storage
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for atorvastatin overdose. In case of an overdose, symptomatic and supportive measures should be initiated as necessary. Liver function tests and CK levels should be monitored.
Pregnancy & Lactation
Atorvastatin is contraindicated during pregnancy (Pregnancy Category X) due to the potential for fetal harm. It is also contraindicated in breastfeeding mothers as it may pass into breast milk and cause adverse effects in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, specific details on packaging.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Atorvastatin has been extensively studied in numerous large-scale clinical trials (e.g., ASCOT-LLA, CARDS, TNT, MIRACL) demonstrating its efficacy in reducing cardiovascular events and mortality in various patient populations.
Lab Monitoring
- Liver function tests (ALT, AST) should be performed before initiating treatment and periodically thereafter.
- Lipid panel (LDL-C, HDL-C, Triglycerides) to assess therapeutic response.
- Creatine Kinase (CK) levels should be measured if muscle pain, tenderness, or weakness occurs.
Doctor Notes
- Monitor liver function tests (LFTs) at baseline and as clinically indicated. Discontinue if transaminase levels persist at >3 times ULN.
- Advise patients to report any muscle pain, tenderness, or weakness. Check CK levels if myopathy is suspected.
- Consider potential drug interactions, especially with CYP3A4 inhibitors and other lipid-lowering agents.
- Emphasize the importance of lifestyle modifications alongside medication.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor, do not stop without consultation.
- Report any unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or dark urine.
- Avoid consuming large amounts of grapefruit or grapefruit juice while on this medication.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Trilock is generally not expected to impair the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy diet low in saturated and trans fats.
- Engage in regular physical activity.
- Achieve and maintain a healthy weight.
- Quit smoking and limit alcohol consumption.
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