Trilock
Generic Name
Montelukast
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trilock 4 mg oral granules | ৳ 8.06 | N/A |
Description
Overview of the medicine
Montelukast is an orally active compound that inhibits leukotriene receptors, reducing inflammation and bronchoconstriction in asthma and allergic rhinitis.
Uses & Indications
Dosage
Adults
Montelukast 4 mg oral granules is typically prescribed for children aged 2-5 years. For adults and adolescents (15 years and older), the recommended dose of Montelukast is 10 mg once daily (usually a tablet form).
Elderly
No dosage adjustment generally required for Montelukast in elderly patients.
Renal_impairment
No dosage adjustment required for Montelukast in patients with renal impairment.
How to Take
Granules can be administered directly into the mouth, dissolved in a spoonful of cold or room temperature soft food (e.g., applesauce, ice cream, rice), or dissolved in breast milk or infant formula. Should be taken in the evening for asthma/rhinitis, or at least 2 hours before exercise for EIB.
Mechanism of Action
Selectively antagonizes cysteinyl leukotriene type 1 (CysLT1) receptors, preventing the actions of leukotrienes (LTC4, LTD4, LTE4), which are potent inflammatory mediators released from cells like mast cells and eosinophils.
Pharmacokinetics
Onset
Clinical improvement within one day for asthma.
Excretion
Primarily excreted in feces (about 86%) via bile; <0.2% excreted in urine.
Half life
Approximately 2.7 to 5.5 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentration reached in about 2-4 hours for granules.
Metabolism
Extensively metabolized in the liver by CYP2C8, CYP3A4, and CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to montelukast or any component of the formulation.
- Not for use in acute asthma attacks (not a rescue medication).
Drug Interactions
Phenobarbital, Rifampin
May decrease montelukast plasma levels.
Gemfibrozil, Itraconazole
May increase montelukast plasma levels, but usually not clinically significant.
Storage
Store at room temperature (below 30°C), protect from moisture and light. Keep out of reach of children.
Overdose
Symptoms are usually mild and may include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed after consulting a doctor. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to montelukast or any component of the formulation.
- Not for use in acute asthma attacks (not a rescue medication).
Drug Interactions
Phenobarbital, Rifampin
May decrease montelukast plasma levels.
Gemfibrozil, Itraconazole
May increase montelukast plasma levels, but usually not clinically significant.
Storage
Store at room temperature (below 30°C), protect from moisture and light. Keep out of reach of children.
Overdose
Symptoms are usually mild and may include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed after consulting a doctor. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to the expiry date on the packaging.
Availability
Pharmacies, Hospitals
Approval Status
FDA and DGDA approved
Patent Status
Patent expired, available as generics
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of montelukast in pediatric and adult patients for asthma and allergic rhinitis.
Lab Monitoring
- No routine laboratory monitoring is typically required for Montelukast.
Doctor Notes
- Educate patients and caregivers about the potential for neuropsychiatric side effects and to seek immediate medical attention if they occur.
- Emphasize that Montelukast is for maintenance therapy and not for acute bronchospasm relief.
- Ensure patient adherence to prescribed dosage and administration instructions.
Patient Guidelines
- Take as prescribed, usually once daily in the evening.
- Do not use for acute asthma attacks; continue using rescue inhalers as needed.
- Report any mood changes, behavioral changes, or suicidal thoughts immediately to a doctor.
- Continue other asthma medications unless advised otherwise by your doctor.
Missed Dose Advice
If a dose is missed, take the next dose at the regular time. Do not take a double dose to make up for a missed one.
Driving Precautions
Montelukast may cause dizziness or drowsiness in some individuals. Patients should be cautious when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Avoid known triggers for asthma and allergies.
- Maintain a healthy lifestyle with regular exercise (if appropriate) and a balanced diet.
- Discuss any concerns about your condition or medication with your healthcare provider.
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