Trospi
Generic Name
Trospi
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trospi 20 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Trospi (Trospium chloride) is a muscarinic receptor antagonist used to treat overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency.
Uses & Indications
Dosage
Adults
20 mg twice daily, approximately one hour before meals, on an empty stomach.
Elderly
No specific dosage adjustment required, but caution advised.
Renal_impairment
For severe renal impairment (CrCl < 30 mL/min), reduce dose to 20 mg once daily.
How to Take
Take orally, with water, on an empty stomach at least one hour before a meal or two hours after a meal. Do not crush or chew tablets.
Mechanism of Action
Trospi acts by competitively binding to muscarinic acetylcholine receptors, primarily M2 and M3, located on the detrusor muscle of the bladder. This blocks the effect of acetylcholine, leading to relaxation of the detrusor muscle and inhibition of involuntary bladder contractions, thereby increasing bladder capacity.
Pharmacokinetics
Onset
Clinical effects typically observed within 1-2 weeks.
Excretion
Primarily excreted unchanged via the kidneys.
Half life
Approximately 18 hours (for immediate-release formulation).
Absorption
Poorly absorbed from the gastrointestinal tract (bioavailability approx. 10%). Peak plasma concentrations reached within 4-6 hours.
Metabolism
Minimally metabolized; some ester hydrolysis and conjugation occur.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Known hypersensitivity to Trospi (Trospium chloride) or any component of the formulation
Drug Interactions
Digoxin
May increase serum concentration of digoxin due to competition for renal tubular secretion.
Anticholinergic agents
Additive anticholinergic effects; avoid concomitant use.
Drugs that are actively secreted by the kidney (e.g., procainamide, vancomycin, metformin)
Potential for altered pharmacokinetics due to competition for renal tubular secretion.
Storage
Store at room temperature (below 30°C), protect from moisture and light. Keep out of reach of children.
Overdose
Symptoms may include severe anticholinergic effects (e.g., blurred vision, dry mouth, urinary retention, tachycardia). Treatment is symptomatic and supportive; gastric lavage and activated charcoal may be considered. Physostigmine may be used as an antidote in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is not known whether Trospi (Trospium) is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Known hypersensitivity to Trospi (Trospium chloride) or any component of the formulation
Drug Interactions
Digoxin
May increase serum concentration of digoxin due to competition for renal tubular secretion.
Anticholinergic agents
Additive anticholinergic effects; avoid concomitant use.
Drugs that are actively secreted by the kidney (e.g., procainamide, vancomycin, metformin)
Potential for altered pharmacokinetics due to competition for renal tubular secretion.
Storage
Store at room temperature (below 30°C), protect from moisture and light. Keep out of reach of children.
Overdose
Symptoms may include severe anticholinergic effects (e.g., blurred vision, dry mouth, urinary retention, tachycardia). Treatment is symptomatic and supportive; gastric lavage and activated charcoal may be considered. Physostigmine may be used as an antidote in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is not known whether Trospi (Trospium) is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved (FDA, DGDA)
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Trospi (Trospium chloride) in treating OAB. Studies have shown significant improvements in OAB symptoms compared to placebo.
Lab Monitoring
- No specific routine lab monitoring required. Monitor for signs of urinary retention or other adverse anticholinergic effects.
Doctor Notes
- Counsel patients on proper administration (empty stomach).
- Assess for potential drug interactions, especially with other anticholinergic agents.
- Monitor for signs of urinary retention.
Patient Guidelines
- Take medicine exactly as prescribed.
- Take on an empty stomach.
- Do not stop taking without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause blurred vision, dizziness, or drowsiness. Patients should be cautioned about engaging in activities requiring mental alertness such as driving or operating machinery until they know how the drug affects them.
Lifestyle Advice
- Limit caffeine and alcohol intake.
- Maintain a healthy weight.
- Practice bladder training techniques if advised by your doctor.
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