Trum-3
Generic Name
Ceftriaxone
Manufacturer
Opsonin Pharma Limited
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trum 3 1 gm injection | ৳ 230.00 | N/A |
Description
Overview of the medicine
Trum-3 1 gm Injection contains Ceftriaxone, a broad-spectrum third-generation cephalosporin antibiotic. It is used to treat various bacterial infections including severe infections, susceptible to ceftriaxone.
Uses & Indications
Dosage
Adults
Usual adult dose is 1-2 gm once daily (or in two equally divided doses) depending on the type and severity of infection, up to a maximum of 4 gm per day. Administer by IM or IV route.
Elderly
No dosage adjustment is generally required for elderly patients with normal renal and hepatic function.
Renal_impairment
No dosage adjustment necessary for patients with renal impairment provided hepatic function is normal. For severe renal impairment (creatinine clearance <10 mL/min), dosage should not exceed 2 gm daily.
How to Take
For Intramuscular (IM) injection: Dissolve 1 gm in 3.5 mL of 1% Lidocaine HCl solution. Inject deeply into a large muscle. For Intravenous (IV) injection: Dissolve 1 gm in 10 mL of sterile water for injection. Administer slowly over 2-4 minutes directly into a vein or through an existing IV line. For IV infusion: Dilute with compatible IV fluids and infuse over 30 minutes.
Mechanism of Action
Ceftriaxone is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This leads to the disruption of the bacterial cell wall and eventual cell lysis.
Pharmacokinetics
Onset
Rapid, typically within 1 hour after IV administration.
Excretion
Approximately 50-60% excreted unchanged in urine, and 40-50% in bile/feces.
Half life
Approximately 6-9 hours (prolonged in neonates and elderly).
Absorption
Rapid and complete absorption after intramuscular (IM) or intravenous (IV) administration.
Metabolism
Partially metabolized in the liver, primarily to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to ceftriaxone, any other cephalosporins, or any component of the formulation.
- Neonates with hyperbilirubinemia, especially premature neonates (due to risk of bilirubin encephalopathy).
- Neonates requiring calcium-containing IV solutions (due to risk of precipitation).
Drug Interactions
Aminoglycosides
Synergistic effect, but should not be mixed in the same syringe or infusion solution.
Calcium-containing solutions
Ceftriaxone should not be mixed or co-administered with calcium-containing solutions or products, even via different infusion lines, in neonates. In other patient populations, separate administration times are recommended.
Loop diuretics (e.g., Furosemide)
Increased risk of nephrotoxicity with concomitant use, especially in patients with pre-existing renal dysfunction.
Oral anticoagulants (e.g., Warfarin)
May increase the anticoagulant effect, requiring closer monitoring of INR and prothrombin time.
Storage
Store below 30°C in a dry place, protected from light. Keep out of the reach of children. Reconstituted solution should be used immediately or within specified time if refrigerated.
Overdose
In case of overdose, symptoms may include nausea, vomiting, and diarrhea. Management is primarily supportive and symptomatic. Hemodialysis or peritoneal dialysis is not effective in removing ceftriaxone from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Excreted in low concentrations in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to ceftriaxone, any other cephalosporins, or any component of the formulation.
- Neonates with hyperbilirubinemia, especially premature neonates (due to risk of bilirubin encephalopathy).
- Neonates requiring calcium-containing IV solutions (due to risk of precipitation).
Drug Interactions
Aminoglycosides
Synergistic effect, but should not be mixed in the same syringe or infusion solution.
Calcium-containing solutions
Ceftriaxone should not be mixed or co-administered with calcium-containing solutions or products, even via different infusion lines, in neonates. In other patient populations, separate administration times are recommended.
Loop diuretics (e.g., Furosemide)
Increased risk of nephrotoxicity with concomitant use, especially in patients with pre-existing renal dysfunction.
Oral anticoagulants (e.g., Warfarin)
May increase the anticoagulant effect, requiring closer monitoring of INR and prothrombin time.
Storage
Store below 30°C in a dry place, protected from light. Keep out of the reach of children. Reconstituted solution should be used immediately or within specified time if refrigerated.
Overdose
In case of overdose, symptoms may include nausea, vomiting, and diarrhea. Management is primarily supportive and symptomatic. Hemodialysis or peritoneal dialysis is not effective in removing ceftriaxone from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Excreted in low concentrations in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, check specific product packaging.
Availability
Hospitals, pharmacies
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of Ceftriaxone for various bacterial infections since its introduction.
Lab Monitoring
- Complete blood count (CBC) with differential, especially during prolonged therapy.
- Renal and hepatic function tests periodically, particularly in patients with pre-existing impairment.
- Prothrombin time (PT) / International Normalized Ratio (INR) for patients on anticoagulants.
Doctor Notes
- Always perform a thorough patient history regarding allergies to beta-lactam antibiotics before administration.
- Monitor for signs of C. difficile-associated diarrhea (CDAD) during and after therapy.
- Avoid co-administration with calcium-containing solutions, especially in neonates, due to precipitation risk.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Report any severe or persistent side effects to your doctor.
- Do not use leftover medication for other infections.
- Inform your doctor about all medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If a dose is missed, it should be administered as soon as possible. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Ceftriaxone generally does not affect the ability to drive or operate machinery. However, if you experience side effects like dizziness or headache, avoid these activities until you feel well.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Drink plenty of fluids unless otherwise advised by your doctor.
- Avoid alcohol during treatment as it may exacerbate some side effects (e.g., gastrointestinal upset).
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Trum-3 Brand
Other medicines available under the same brand name
