Truso DS
Generic Name
Azithromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| truso ds 200 mg suspension | ৳ 280.84 | N/A |
Description
Overview of the medicine
Truso DS (Azithromycin) is a macrolide antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases.
Uses & Indications
Dosage
Adults
Typically 500 mg once daily for 3 days, or 500 mg on day 1 followed by 250 mg once daily for 4 days.
Elderly
No dosage adjustment needed for elderly patients with normal renal and hepatic function.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment. Caution in severe impairment.
How to Take
Can be taken with or without food. To minimize gastrointestinal upset, it may be taken with food.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thus preventing the growth of bacteria.
Pharmacokinetics
Onset
Onset of action within 2-3 hours.
Excretion
Mainly excreted unchanged in bile, minor renal excretion.
Half life
Terminal elimination half-life is 2-4 days.
Absorption
Well absorbed orally, bioavailability is approximately 37%.
Metabolism
Primarily hepatic metabolism, demethylation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased azithromycin concentrations.
Cyclosporine, Digoxin, Ergot alkaloids
Potential for increased levels of these drugs; monitor closely.
Antacids (aluminum and magnesium containing)
May reduce peak serum levels of azithromycin; administer azithromycin at least 1 hour before or 2 hours after antacids.
Storage
Store in a cool, dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased azithromycin concentrations.
Cyclosporine, Digoxin, Ergot alkaloids
Potential for increased levels of these drugs; monitor closely.
Antacids (aluminum and magnesium containing)
May reduce peak serum levels of azithromycin; administer azithromycin at least 1 hour before or 2 hours after antacids.
Storage
Store in a cool, dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of azithromycin for its approved indications.
Lab Monitoring
- Liver function tests (LFTs) if prolonged use or pre-existing hepatic impairment
- Renal function tests if severe renal impairment
- INR for patients on warfarin
Doctor Notes
- Advise patients to report any signs of allergic reactions or severe diarrhea immediately.
- Consider drug interactions, especially with warfarin and QT-prolonging agents.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Do not share this medicine with others.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness in some individuals. Exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Stay hydrated.
- Avoid alcohol during treatment if experiencing gastrointestinal upset.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.