Tuscof
Generic Name
Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Chlorpheniramine Maleate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tuscof 100 mg syrup | ৳ 85.00 | N/A |
Description
Overview of the medicine
Tuscof is a combination medication used to relieve symptoms associated with common cold, allergic rhinitis, and other respiratory tract allergies. It helps to suppress cough, relieve nasal congestion, and alleviate allergic symptoms like sneezing and runny nose.
Uses & Indications
Dosage
Adults
10 ml (2 teaspoonfuls) 3-4 times daily.
Elderly
Use with caution; consider lower doses due to potential increased sensitivity to side effects.
Renal_impairment
Use with caution; dose adjustment may be necessary in severe renal impairment.
How to Take
Administer orally. Measure the dose accurately using a measuring spoon or cup. Can be taken with or without food.
Mechanism of Action
Dextromethorphan acts centrally on the cough center in the medulla to elevate the cough threshold. Phenylephrine is an alpha-adrenergic agonist that causes vasoconstriction, leading to reduced nasal mucosal swelling. Chlorpheniramine maleate is an antihistamine that blocks H1 receptors, thereby reducing allergic reactions like sneezing and runny nose.
Pharmacokinetics
Onset
Approximately 15-30 minutes.
Excretion
Mainly excreted renally as unchanged drug or metabolites.
Half life
Dextromethorphan: 2-4 hours; Phenylephrine: 2-3 hours; Chlorpheniramine: 12-43 hours.
Absorption
Well absorbed orally. Dextromethorphan undergoes rapid absorption; Phenylephrine has variable oral absorption; Chlorpheniramine is well absorbed.
Metabolism
Primarily hepatic metabolism. Dextromethorphan by CYP2D6; Phenylephrine by MAO; Chlorpheniramine by extensive first-pass metabolism.
Side Effects
Contraindications
- Hypersensitivity to any of the ingredients
- Patients taking Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping MAOI therapy
- Severe hypertension or severe coronary artery disease
- Narrow-angle glaucoma
Drug Interactions
MAOIs
Concomitant use can lead to hypertensive crisis or serotonin syndrome.
Beta-blockers
May enhance the pressor effects of Phenylephrine.
CNS Depressants
Increased sedative effects with alcohol, tranquilizers, hypnotics, and other CNS depressants.
Antidepressants (e.g., TCAs, SSRIs)
Increased risk of serotonin syndrome with Dextromethorphan.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, nausea, vomiting, tachycardia, hypertension, nervousness, hallucinations, and convulsions. Management involves symptomatic and supportive treatment, including gastric lavage or activated charcoal.
Pregnancy & Lactation
Pregnancy Category C. Not recommended for use during pregnancy or lactation unless clearly indicated and potential benefits outweigh risks. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to any of the ingredients
- Patients taking Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping MAOI therapy
- Severe hypertension or severe coronary artery disease
- Narrow-angle glaucoma
Drug Interactions
MAOIs
Concomitant use can lead to hypertensive crisis or serotonin syndrome.
Beta-blockers
May enhance the pressor effects of Phenylephrine.
CNS Depressants
Increased sedative effects with alcohol, tranquilizers, hypnotics, and other CNS depressants.
Antidepressants (e.g., TCAs, SSRIs)
Increased risk of serotonin syndrome with Dextromethorphan.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, nausea, vomiting, tachycardia, hypertension, nervousness, hallucinations, and convulsions. Management involves symptomatic and supportive treatment, including gastric lavage or activated charcoal.
Pregnancy & Lactation
Pregnancy Category C. Not recommended for use during pregnancy or lactation unless clearly indicated and potential benefits outweigh risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in all pharmacies
Approval Status
Approved by DGDA
Patent Status
Generic, no longer patented
Clinical Trials
Ingredients are well-established. Clinical trials focus on efficacy and safety in specific patient populations or new formulations, but core safety and efficacy are widely known.
Lab Monitoring
- No specific laboratory monitoring is generally required for routine use. Monitor blood pressure in patients with hypertension.
Doctor Notes
- Use with caution in patients with hypertension, diabetes, thyroid disorders, glaucoma, prostatic hypertrophy, or asthma.
- Advise patients about potential drowsiness and to avoid alcohol.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid operating machinery or driving if experiencing drowsiness.
- Consult a doctor if symptoms do not improve within 7 days or worsen.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause drowsiness or dizziness. Do not drive or operate heavy machinery until you know how this medication affects you.
Lifestyle Advice
- Ensure adequate hydration by drinking plenty of fluids.
- Get sufficient rest to aid recovery from cold symptoms.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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