Tysinor
Generic Name
Neurozin Hydrochloride
Manufacturer
MediCorp Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tysinor 150 mg tablet | ৳ 60.00 | ৳ 480.00 |
Description
Overview of the medicine
Tysinor 150 mg tablet contains Neurozin Hydrochloride, a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder, generalized anxiety disorder, and certain neuropathic pain conditions.
Uses & Indications
Dosage
Adults
Initial dose 75 mg once daily, may be increased to 150 mg once daily based on response. Maximum 300 mg daily.
Elderly
Lower starting dose (e.g., 37.5 mg) with gradual titration, close monitoring for adverse effects.
Renal_impairment
Dose adjustment required. For severe impairment, consider reducing dose by 50% or more.
How to Take
Take orally, once daily, with or without food. Swallow the tablet whole; do not crush, chew, or divide.
Mechanism of Action
Neurozin acts by inhibiting the reuptake of serotonin and norepinephrine in the central nervous system, thereby increasing the concentration of these neurotransmitters in the synaptic cleft. This leads to an improvement in mood and a reduction in anxiety and pain.
Pharmacokinetics
Onset
Therapeutic effects typically observed within 1-2 weeks, full effect may take 4-6 weeks.
Excretion
Mainly excreted renally as metabolites.
Half life
Approximately 10-15 hours for the active compound.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Neurozin or any component of the formulation.
- Concurrent use of Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
Drug Interactions
MAOIs
Concomitant use is contraindicated due to risk of serotonin syndrome.
Warfarin
May increase anticoagulant effect, monitor INR.
Serotonergic drugs (e.g., SSRIs, Triptans)
Increased risk of serotonin syndrome.
CNS depressants (e.g., Alcohol, Benzodiazepines)
Additive CNS depression, avoid concomitant use.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, dizziness, tachycardia, seizures, and serotonin syndrome. Treatment is supportive and symptomatic; ensure adequate airway, ventilation, and oxygenation. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Neurozin or any component of the formulation.
- Concurrent use of Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
Drug Interactions
MAOIs
Concomitant use is contraindicated due to risk of serotonin syndrome.
Warfarin
May increase anticoagulant effect, monitor INR.
Serotonergic drugs (e.g., SSRIs, Triptans)
Increased risk of serotonin syndrome.
CNS depressants (e.g., Alcohol, Benzodiazepines)
Additive CNS depression, avoid concomitant use.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, dizziness, tachycardia, seizures, and serotonin syndrome. Treatment is supportive and symptomatic; ensure adequate airway, ventilation, and oxygenation. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by national regulatory authority
Patent Status
Under patent protection
Clinical Trials
Extensive clinical trials (Phase I, II, III) have demonstrated its efficacy and safety profile for approved indications. Post-marketing surveillance is ongoing.
Lab Monitoring
- Monitor blood pressure regularly, especially during dose titration.
- Liver function tests periodically in patients with hepatic impairment.
Doctor Notes
- Counsel patients on potential for increased suicidal ideation, especially at the start of therapy or dose changes.
- Monitor blood pressure regularly due to risk of dose-dependent hypertension.
- Advise patients on gradual tapering when discontinuing to minimize withdrawal symptoms.
Patient Guidelines
- Take Tysinor exactly as prescribed by your doctor.
- Do not stop taking this medicine abruptly without consulting your doctor, as it may lead to withdrawal symptoms.
- Report any worsening mood, suicidal thoughts, or unusual changes in behavior to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Tysinor may cause dizziness, drowsiness, or visual disturbances. Patients should exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain a healthy lifestyle with regular exercise and a balanced diet.
- Practice stress-reducing techniques such as meditation or yoga.
- Avoid alcohol while taking this medication.
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