Tysinor
Generic Name
Paracetamol
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tysinor 500 mg tablet | ৳ 120.00 | ৳ 960.00 |
Description
Overview of the medicine
Tysinor 500 mg tablet contains Paracetamol, which is used for the relief of mild to moderate pain and to reduce fever.
Uses & Indications
Dosage
Adults
1-2 tablets (500-1000 mg) every 4-6 hours as needed. Do not exceed 8 tablets (4000 mg) in 24 hours.
Elderly
Similar to adult dosage, but caution should be exercised in patients with impaired hepatic or renal function.
Renal_impairment
Dosage interval may need to be extended. For severe renal impairment, consider extending the interval to 6-8 hours. Consult a doctor.
How to Take
Take the tablet orally with water. It can be taken with or without food. Do not crush or chew the tablet.
Mechanism of Action
Paracetamol is thought to act primarily by inhibiting prostaglandin synthesis in the central nervous system, which leads to its analgesic and antipyretic effects. It has weak anti-inflammatory effects.
Pharmacokinetics
Onset
Analgesic effect begins within 30-60 minutes; antipyretic effect within 30 minutes.
Excretion
Excreted mainly by the kidneys as glucuronide and sulfate conjugates (90-100% within 24 hours).
Half life
Plasma elimination half-life is 1-4 hours in individuals with normal liver function.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation (45-55%) and sulfation (20-30%). A small amount is metabolized by cytochrome P450 to a highly reactive intermediate (NAPQI), which is detoxified by conjugation with glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any other component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Chronic alcohol consumption increases the risk of hepatotoxicity.
Lamotrigine
Paracetamol may reduce the half-life of lamotrigine.
Cholestyramine
Reduces paracetamol absorption if taken within one hour of paracetamol.
Warfarin and other coumarins
May increase the anticoagulant effect and risk of bleeding with prolonged regular daily use, requiring INR monitoring.
Metoclopramide and Domperidone
Increase the rate of paracetamol absorption.
Isoniazid, Phenytoin, Carbamazepine, Barbiturates
May increase the risk of paracetamol hepatotoxicity.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose of paracetamol can cause severe, potentially fatal liver damage (hepatotoxicity). Symptoms may not appear for up to 24-48 hours and include nausea, vomiting, abdominal pain, and sweating. In case of suspected overdose, seek immediate medical attention. Treatment involves activated charcoal (if administered early) and N-acetylcysteine.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation when used at recommended doses for the shortest possible duration. However, pregnant or breastfeeding women should consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any other component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Chronic alcohol consumption increases the risk of hepatotoxicity.
Lamotrigine
Paracetamol may reduce the half-life of lamotrigine.
Cholestyramine
Reduces paracetamol absorption if taken within one hour of paracetamol.
Warfarin and other coumarins
May increase the anticoagulant effect and risk of bleeding with prolonged regular daily use, requiring INR monitoring.
Metoclopramide and Domperidone
Increase the rate of paracetamol absorption.
Isoniazid, Phenytoin, Carbamazepine, Barbiturates
May increase the risk of paracetamol hepatotoxicity.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose of paracetamol can cause severe, potentially fatal liver damage (hepatotoxicity). Symptoms may not appear for up to 24-48 hours and include nausea, vomiting, abdominal pain, and sweating. In case of suspected overdose, seek immediate medical attention. Treatment involves activated charcoal (if administered early) and N-acetylcysteine.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation when used at recommended doses for the shortest possible duration. However, pregnant or breastfeeding women should consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 36 months from the date of manufacture. Check the expiry date on the packaging.
Availability
Pharmacies, supermarkets
Approval Status
Approved (Commonly available OTC)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Paracetamol has been extensively studied for decades, and its efficacy and safety profile are well-established. Numerous clinical trials support its use as an analgesic and antipyretic.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) in cases of overdose or prolonged high-dose therapy.
- Renal function tests if long-term use in patients with pre-existing renal impairment.
Doctor Notes
- Advise patients to check all other medications for paracetamol to avoid accidental overdose.
- Caution in patients with pre-existing liver disease or chronic alcohol abuse.
- Educate patients on the symptoms of liver toxicity and when to seek medical attention.
Patient Guidelines
- Always read the label and follow the instructions carefully.
- Do not exceed the stated dose.
- Avoid taking other paracetamol-containing products at the same time.
- If symptoms persist for more than 3 days (fever) or 5 days (pain), consult a doctor.
- Keep out of reach of children.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Tysinor is not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or drowsiness (which are rare side effects), do not drive or operate machinery.
Lifestyle Advice
- Avoid or limit alcohol consumption while taking paracetamol, especially with regular use.
- Maintain adequate hydration, especially when experiencing fever.
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