Ulsec
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ulsec 1000 mg tablet | ৳ 6.00 | ৳ 36.00 |
Description
Overview of the medicine
Ulsec contains Omeprazole, a proton pump inhibitor, used to reduce stomach acid production and treat conditions like ulcers, GERD, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
For GERD: 20 mg once daily for 4-8 weeks. For duodenal ulcer: 20 mg once daily for 2-4 weeks. For gastric ulcer: 20 mg once daily for 4-8 weeks. For Zollinger-Ellison syndrome: Initial 60 mg once daily, adjust as needed.
Elderly
No specific dose adjustment is usually required, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dose adjustment is generally required for renal impairment.
How to Take
Take orally, preferably in the morning before a meal. Swallow the capsule whole with water; do not chew or crush.
Mechanism of Action
Omeprazole is a proton pump inhibitor that irreversibly blocks the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted in urine as metabolites, a small amount in feces.
Half life
Approximately 0.5-1 hour, but duration of acid suppression is much longer due to irreversible binding.
Absorption
Rapidly absorbed from the small intestine. Bioavailability is approximately 30-40% after a single dose and increases with repeated administration.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Omeprazole or any component of the formulation
- Concomitant use with Nelfinavir
Drug Interactions
Warfarin
Increased INR/bleeding risk.
Clopidogrel
Reduced antiplatelet effect.
Methotrexate
Increased methotrexate levels.
Ketoconazole, Itraconazole
Reduced absorption due to altered gastric pH.
Diazepam, Phenytoin, Citalopram
Increased levels of these drugs.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Excreted in breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to Omeprazole or any component of the formulation
- Concomitant use with Nelfinavir
Drug Interactions
Warfarin
Increased INR/bleeding risk.
Clopidogrel
Reduced antiplatelet effect.
Methotrexate
Increased methotrexate levels.
Ketoconazole, Itraconazole
Reduced absorption due to altered gastric pH.
Diazepam, Phenytoin, Citalopram
Increased levels of these drugs.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Excreted in breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
FDA/DGDA approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Omeprazole's efficacy and safety for various acid-related disorders.
Lab Monitoring
- Magnesium levels (for long-term use)
- Vitamin B12 levels (for long-term use)
- Liver function tests (if hepatic impairment suspected)
Doctor Notes
- Consider potential drug interactions, especially with Warfarin and Clopidogrel.
- Advise patients on long-term therapy about risks of fractures and nutrient deficiencies.
- Review necessity of continued PPI therapy periodically.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking without consulting your doctor, even if you feel better.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.
Driving Precautions
May cause dizziness or visual disturbances in some patients. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid spicy, fatty foods, and caffeine to reduce acid reflux.
- Elevate the head of your bed to help with GERD symptoms.
- Maintain a healthy weight.
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Global Brand Names
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