Ultra-D
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ultra d 20000 iu capsule | ৳ 17.50 | ৳ 175.00 |
Description
Overview of the medicine
Ultra-D 20000 IU Capsule contains Cholecalciferol (Vitamin D3), a vital fat-soluble vitamin essential for calcium and phosphate absorption, bone health, and immune system function. It is primarily used to treat and prevent vitamin D deficiency, osteomalacia, rickets, and as a supplement in conditions like osteoporosis.
Uses & Indications
Dosage
Adults
For severe vitamin D deficiency: 20000 IU once weekly for 7 weeks, followed by maintenance dose as per physician's advice (e.g., 800-2000 IU daily or equivalent weekly/monthly). For osteoporosis: 20000 IU once weekly or bi-weekly as directed by physician.
Elderly
Same as adults, but may require closer monitoring of vitamin D levels and calcium.
Renal_impairment
Use with caution. Dosage may need adjustment. Monitor calcium and phosphate levels closely.
How to Take
To be taken orally, preferably with the largest meal of the day to enhance absorption. Do not chew or crush the capsule, swallow whole with water.
Mechanism of Action
Cholecalciferol (Vitamin D3) is biologically inactive and is converted in the liver to 25-hydroxycholecalciferol (calcidiol), and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form. Calcitriol acts by binding to the vitamin D receptor (VDR), regulating calcium and phosphate homeostasis, promoting their absorption from the gut, and facilitating bone mineralization.
Pharmacokinetics
Onset
Effects on calcium and phosphate levels typically seen within days to weeks, peak calcitriol levels reached within hours.
Excretion
Primarily excreted in bile and feces; a small amount is excreted in urine.
Half life
The half-life of 25-hydroxyvitamin D3 (calcidiol) is about 15-30 days; the active form 1,25-dihydroxyvitamin D3 (calcitriol) has a half-life of about 4-6 hours.
Absorption
Readily absorbed from the small intestine, primarily in the presence of bile salts and dietary fat.
Metabolism
Metabolized in the liver to 25-hydroxycholecalciferol (calcidiol) and subsequently in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form. Further metabolism inactivates the vitamin.
Side Effects
Contraindications
- •Hypercalcaemia (high calcium levels in blood)
- •Hypervitaminosis D (vitamin D toxicity)
- •Nephrolithiasis (kidney stones)
- •Severe renal impairment
- •Hypersensitivity to cholecalciferol or any excipients
Drug Interactions
Corticosteroids
May reduce the effects of vitamin D.
Thiazide diuretics
May increase the risk of hypercalcaemia due to reduced urinary calcium excretion.
Digitalis glycosides
Increased risk of digitalis toxicity due to hypercalcaemia.
Phenytoin, barbiturates
May accelerate vitamin D metabolism, reducing its effects.
Cholestyramine, colestipol, orlistat, paraffin oil
May impair absorption of vitamin D.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcaemia (nausea, vomiting, constipation, polyuria, polydipsia, anorexia, weakness, headache, confusion), hypercalciuria, and ultimately kidney damage. Treatment involves discontinuation of vitamin D, hydration, and management of hypercalcaemia with diuretics or corticosteroids if severe.
Pregnancy & Lactation
Pregnancy Category C. Vitamin D is essential during pregnancy and lactation. High doses should be used only if clearly needed and under medical supervision, with careful monitoring of maternal and fetal calcium levels. Excess vitamin D may be harmful to the fetus.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic
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