Ultra-D
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
General Pharmaceutical Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ultra d 40000 iu capsule | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Ultra-D 40000 IU Capsule is a high-strength vitamin D3 supplement used to treat and prevent vitamin D deficiency, promote bone health, and support immune function.
Uses & Indications
Dosage
Adults
For vitamin D deficiency, typically one 40000 IU capsule once weekly or once every two to four weeks, or as directed by a physician, based on individual serum 25(OH)D levels.
Elderly
No specific dosage adjustment is generally required for elderly patients, but renal function should be monitored.
Renal_impairment
Use with caution. Dose adjustment may be necessary in severe renal impairment, and monitoring of calcium and phosphate levels is crucial.
How to Take
Take the capsule orally with a full glass of water. It is best taken with a meal (preferably the largest meal of the day) to enhance absorption.
Mechanism of Action
Cholecalciferol is converted in the body to calcitriol, the active form of vitamin D. Calcitriol enhances the absorption of calcium and phosphate from the intestine, regulates bone mineralization, and plays a role in various cellular functions, including immune response.
Pharmacokinetics
Onset
Clinical effects may take several days to weeks to manifest, as repletion of vitamin D stores and subsequent metabolic processes occur.
Excretion
Primarily excreted in bile and feces, mainly as inactive metabolites. A small amount is excreted in urine.
Half life
The elimination half-life of 25-hydroxyvitamin D (calcifediol), the major circulating form, is approximately 15-20 days. The half-life of 1,25-dihydroxyvitamin D (calcitriol) is shorter, about 4-6 hours.
Absorption
Well absorbed from the small intestine, especially when taken with fatty meals.
Metabolism
Initially hydroxylated in the liver to 25-hydroxyvitamin D (calcifediol), then further hydroxylated in the kidney to 1,25-dihydroxyvitamin D (calcitriol), the biologically active form.
Side Effects
Contraindications
- •Hypercalcemia (high levels of calcium in the blood)
- •Vitamin D toxicity
- •Hypersensitivity to cholecalciferol or any of the excipients
- •Nephrolithiasis (kidney stones) or nephrocalcinosis (calcium deposits in the kidneys)
Drug Interactions
Corticosteroids
May reduce the effect of vitamin D.
Thiazide diuretics
May increase the risk of hypercalcemia.
Phenytoin and Barbiturates
May increase the metabolism of vitamin D, reducing its effects.
Cardiac glycosides (e.g., Digoxin)
Hypercalcemia can potentiate the effects of cardiac glycosides, increasing toxicity risk.
Cholestyramine, Colestipol, Orlistat, Mineral oil
May reduce the absorption of vitamin D.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (vitamin D toxicity) include hypercalcemia with symptoms like nausea, vomiting, loss of appetite, constipation, weakness, fatigue, polyuria, polydipsia, and headache. Severe cases can lead to kidney damage and cardiac arrhythmias. Management involves discontinuing vitamin D, a low calcium diet, hydration, and medical support.
Pregnancy & Lactation
Vitamin D is essential during pregnancy and lactation. However, high doses (like 40000 IU) should only be used if clearly indicated and under strict medical supervision to avoid potential harm to the fetus or infant. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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