Ultrapime
Generic Name
Cefepime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ultrapime 1 gm injection | ৳ 550.00 | N/A |
Description
Overview of the medicine
Cefepime is a broad-spectrum, fourth-generation cephalosporin antibiotic used to treat various bacterial infections, including complicated and uncomplicated urinary tract infections, pneumonia, skin and skin structure infections, and intra-abdominal infections.
Uses & Indications
Dosage
Adults
1-2 gm IV/IM every 8-12 hours, depending on infection severity. For febrile neutropenia, 2 gm IV every 8 hours.
Elderly
Dosage adjustment required based on renal function, similar to adults with renal impairment.
Renal_impairment
Dosage must be adjusted based on creatinine clearance (e.g., 1 gm every 24 hours for CrCl 30-60 mL/min, 0.5 gm every 24 hours for CrCl 11-29 mL/min).
How to Take
Intravenous (IV) infusion over 30 minutes or Intramuscular (IM) deep injection. Reconstitute powder with appropriate diluent (e.g., Sterile Water for Injection, 0.9% Sodium Chloride).
Mechanism of Action
Cefepime is a bactericidal agent that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), particularly PBP-3, which results in the inhibition of peptidoglycan synthesis, leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Rapid, typically within minutes of IV administration.
Excretion
Primarily renal excretion (85% as unchanged drug in urine).
Half life
Approximately 2 hours in adults with normal renal function.
Absorption
Administered intravenously, providing 100% bioavailability.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefepime, other cephalosporins, penicillins, or other beta-lactam antibiotics.
- Patients with a history of severe immediate hypersensitivity reactions to penicillin.
Drug Interactions
Aminoglycosides
Increased risk of nephrotoxicity and ototoxicity.
Loop Diuretics (e.g., Furosemide)
May increase the risk of nephrotoxicity when co-administered with aminoglycosides.
Oral Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect.
Storage
Store powder at controlled room temperature (20-25°C), protected from light. Reconstituted solution stable for 24 hours at room temperature or 7 days under refrigeration (2-8°C).
Overdose
Symptoms may include encephalopathy, seizures, and neuromuscular excitability. Management involves supportive care and hemodialysis to remove the drug.
Pregnancy & Lactation
Use during pregnancy only if clearly needed after careful risk-benefit assessment. Excreted in breast milk in low concentrations; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to cefepime, other cephalosporins, penicillins, or other beta-lactam antibiotics.
- Patients with a history of severe immediate hypersensitivity reactions to penicillin.
Drug Interactions
Aminoglycosides
Increased risk of nephrotoxicity and ototoxicity.
Loop Diuretics (e.g., Furosemide)
May increase the risk of nephrotoxicity when co-administered with aminoglycosides.
Oral Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect.
Storage
Store powder at controlled room temperature (20-25°C), protected from light. Reconstituted solution stable for 24 hours at room temperature or 7 days under refrigeration (2-8°C).
Overdose
Symptoms may include encephalopathy, seizures, and neuromuscular excitability. Management involves supportive care and hemodialysis to remove the drug.
Pregnancy & Lactation
Use during pregnancy only if clearly needed after careful risk-benefit assessment. Excreted in breast milk in low concentrations; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date when stored correctly.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support its efficacy and safety in various bacterial infections.
Lab Monitoring
- Renal function tests (BUN, creatinine)
- Complete Blood Count (CBC)
- Liver function tests (LFTs) occasionally
- Prothrombin time/INR (if co-administered with anticoagulants)
Doctor Notes
- Consider renal function adjustment in elderly and renally impaired patients.
- Monitor for neurological adverse events, especially in patients with renal impairment or those receiving high doses.
- Culture and sensitivity testing recommended before initiating treatment.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Report any severe diarrhea, rash, or allergic reactions immediately.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered, unless it is almost time for the next scheduled dose. Do not double the dose to catch up.
Driving Precautions
Cefepime may cause dizziness or confusion in some patients; advise caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment if experiencing side effects like nausea.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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