Take the tablet orally, whole, with a glass of water, with or without food. Do not chew, crush, or break the extended-release tablet, as this can lead to rapid absorption and potential toxicity.

Theophylline is a non-selective phosphodiesterase inhibitor and an adenosine receptor antagonist. By inhibiting phosphodiesterase, it increases intracellular cyclic AMP (cAMP) levels, which leads to bronchodilation, smooth muscle relaxation, and inhibition of inflammatory mediator release. As an adenosine receptor antagonist, it also contributes to bronchodilation and modulates inflammation.

• •Hypersensitivity to theophylline or any components of the tablet.
• •Acute myocardial infarction.
• •Uncontrolled seizure disorders.

Store below 30°C, in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Symptoms of overdose include severe nausea, vomiting, persistent headache, restlessness, insomnia, tremor, palpitations, and in severe cases, cardiac arrhythmias and seizures. Management involves discontinuing the drug, activated charcoal to reduce absorption, and supportive care. Hemodialysis or hemoperfusion may be considered for severe or refractory toxicity.

Pregnancy Category C. Theophylline crosses the placenta and is excreted in breast milk. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Monitor breastfed infants for irritability or other signs of toxicity.