Univer
Generic Name
Dexamethasone
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| univer 6 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Univer 6 mg Tablet contains Dexamethasone, a potent synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. It is used to treat a wide range of conditions, including allergic disorders, inflammatory diseases, autoimmune diseases, and certain cancers.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the condition being treated and patient response. Typically ranges from 0.5 mg to 9 mg daily, given as a single dose or in divided doses. For acute severe conditions, higher doses may be used temporarily.
Elderly
Use with caution; lower initial doses may be appropriate due to increased risk of side effects.
Renal_impairment
No specific dose adjustment is usually required, but use with caution in severe renal impairment.
How to Take
Take Univer 6 mg Tablet orally, preferably with food or milk to minimize gastrointestinal upset. Do not crush or chew the tablet. Follow your doctor's instructions regarding dosage and duration.
Mechanism of Action
Dexamethasone acts by binding to glucocorticoid receptors in the cytoplasm, leading to a complex formation that translocates into the nucleus. This complex then modulates the transcription of specific genes, resulting in the inhibition of inflammatory mediators and suppression of immune responses.
Pharmacokinetics
Onset
Within hours of oral administration for anti-inflammatory effects.
Excretion
Mainly excreted in the urine as inactive metabolites.
Half life
Plasma half-life is 3-4.5 hours; biological half-life is 36-54 hours.
Absorption
Well absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours.
Metabolism
Primarily metabolized in the liver by CYP3A4 enzymes.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to Dexamethasone or any component of the tablet
- Live vaccines administration (during high-dose corticosteroid therapy)
Drug Interactions
Warfarin
Potentiates or inhibits anticoagulant effects; monitor INR.
NSAIDs (e.g., Ibuprofen, Aspirin)
Increased risk of gastrointestinal ulceration and bleeding.
CYP3A4 inducers (e.g., Phenytoin, Rifampicin)
May decrease Dexamethasone levels, reducing efficacy.
CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase Dexamethasone levels, enhancing effects and side effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of acute overdose are rare but may include nausea, vomiting, and gastrointestinal bleeding. Long-term overdose can lead to Cushing's syndrome symptoms (e.g., moon face, fluid retention). Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Dexamethasone is excreted in breast milk; caution should be exercised when administered to a nursing mother. Consult your doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to Dexamethasone or any component of the tablet
- Live vaccines administration (during high-dose corticosteroid therapy)
Drug Interactions
Warfarin
Potentiates or inhibits anticoagulant effects; monitor INR.
NSAIDs (e.g., Ibuprofen, Aspirin)
Increased risk of gastrointestinal ulceration and bleeding.
CYP3A4 inducers (e.g., Phenytoin, Rifampicin)
May decrease Dexamethasone levels, reducing efficacy.
CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase Dexamethasone levels, enhancing effects and side effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of acute overdose are rare but may include nausea, vomiting, and gastrointestinal bleeding. Long-term overdose can lead to Cushing's syndrome symptoms (e.g., moon face, fluid retention). Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Dexamethasone is excreted in breast milk; caution should be exercised when administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Dexamethasone has been extensively studied in numerous clinical trials for its efficacy in various inflammatory, allergic, and autoimmune conditions. It is a well-established medicine with a long history of use.
Lab Monitoring
- Blood glucose levels (especially in diabetic patients)
- Electrolyte levels (potassium, sodium)
- Blood pressure
- Bone mineral density (for long-term use)
Doctor Notes
- Always advise patients on the importance of gradual dose tapering to prevent adrenal crisis.
- Monitor blood glucose, electrolytes, and blood pressure regularly, especially in long-term users.
- Consider bone protective agents (e.g., calcium, vitamin D, bisphosphonates) for patients on prolonged high-dose therapy.
- Educate patients about increased susceptibility to infections and symptoms to watch for.
Patient Guidelines
- Do not stop taking Univer 6 mg Tablet abruptly, as this can lead to withdrawal symptoms and adrenal insufficiency. Gradually reduce the dose under medical supervision.
- Take with food or milk to reduce stomach upset.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Report any unusual side effects or worsening of your condition to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Dexamethasone may cause dizziness, vision changes, or mood disturbances in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health.
- Avoid exposure to sick individuals, as corticosteroids can suppress the immune system.
- Engage in regular, moderate exercise if appropriate.
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