Uroblock
Generic Name
Solifenacin Succinate
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| uroblock 25 mg tablet | ৳ 30.00 | ৳ 300.00 |
| uroblock 50 mg tablet | ৳ 55.00 | ৳ 550.00 |
Description
Overview of the medicine
Uroblock (Solifenacin Succinate) is an anticholinergic agent used to treat symptoms of overactive bladder, such as urinary urgency, frequency, and incontinence.
Uses & Indications
Dosage
Adults
Initial dose is 5 mg once daily. May be increased to 10 mg once daily based on efficacy and tolerability.
Elderly
No dosage adjustment is required for elderly patients, but caution is advised.
Renal_impairment
For severe renal impairment (creatinine clearance <30 mL/min), do not exceed 5 mg once daily.
How to Take
Take orally with water, with or without food. Do not chew, crush, or break the tablet.
Mechanism of Action
Solifenacin is a competitive muscarinic receptor antagonist. By inhibiting muscarinic receptors, particularly M3 receptors in the bladder, it reduces involuntary detrusor muscle contractions, thereby decreasing urinary urgency, frequency, and incontinence.
Pharmacokinetics
Onset
Significant effects observed within 1 week, maximal effect within 4-8 weeks.
Excretion
Excreted via urine (approximately 69%) and feces (approximately 23%).
Half life
Approximately 45-68 hours.
Absorption
Well absorbed from the gastrointestinal tract, with an absolute bioavailability of approximately 90%.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 3A4 (CYP3A4).
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Severe hepatic impairment
Drug Interactions
Other anticholinergic agents
May enhance anticholinergic effects.
Prokinetic agents (e.g., Metoclopramide)
May reduce their effect.
Strong CYP3A4 inhibitors (e.g., Ketoconazole)
May increase solifenacin exposure; limit dose to 5 mg.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe anticholinergic effects like dry mouth, blurred vision, urinary retention, and tachycardia. Treatment is symptomatic and supportive; consider gastric lavage and activated charcoal, and administer physostigmine in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is unknown if solifenacin is excreted in human milk.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Severe hepatic impairment
Drug Interactions
Other anticholinergic agents
May enhance anticholinergic effects.
Prokinetic agents (e.g., Metoclopramide)
May reduce their effect.
Strong CYP3A4 inhibitors (e.g., Ketoconazole)
May increase solifenacin exposure; limit dose to 5 mg.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe anticholinergic effects like dry mouth, blurred vision, urinary retention, and tachycardia. Treatment is symptomatic and supportive; consider gastric lavage and activated charcoal, and administer physostigmine in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is unknown if solifenacin is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Patent expired / Generic available
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of solifenacin in treating overactive bladder symptoms.
Lab Monitoring
- No specific routine laboratory monitoring is required. Liver and renal function should be monitored in patients with pre-existing impairment.
Doctor Notes
- Assess for urinary retention before initiating therapy.
- Caution in patients with controlled narrow-angle glaucoma.
- Monitor for anticholinergic side effects, especially in elderly patients.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any severe or bothersome side effects to your doctor.
- Avoid activities requiring mental alertness until you know how the medicine affects you.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause blurred vision, dizziness, or somnolence. Patients should be cautioned about engaging in activities requiring mental alertness, such as driving or operating heavy machinery.
Lifestyle Advice
- Manage fluid intake; avoid excessive caffeine and alcohol.
- Perform pelvic floor exercises (Kegel exercises) as recommended.
- Maintain a healthy body weight.
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International brand names for this medicine. Click a brand to search for detailed information.
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