Utracet
Generic Name
Tramadol Hydrochloride + Paracetamol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| utracet 325 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Utracet is a combination medicine containing Tramadol Hydrochloride and Paracetamol. It is used for the management of moderate to moderately severe pain, often when other pain relievers are insufficient.
Uses & Indications
Dosage
Adults
Recommended initial dose is 1-2 tablets every 4-6 hours as needed for pain relief, not to exceed 8 tablets (300 mg Tramadol/2600 mg Paracetamol) per day.
Elderly
For patients over 75 years, maximum daily dose should not exceed 6 tablets due to risk of increased plasma concentrations.
Renal_impairment
In patients with creatinine clearance <30 mL/min, the dosing interval should be increased to not more than two tablets every 12 hours.
How to Take
Administer orally. Can be taken with or without food.
Mechanism of Action
Tramadol acts as a weak opioid agonist and inhibits the reuptake of norepinephrine and serotonin. Paracetamol inhibits prostaglandin synthesis primarily in the central nervous system, leading to analgesic and antipyretic effects. The combination provides synergistic pain relief.
Pharmacokinetics
Onset
Analgesic effect typically begins within 30-60 minutes.
Excretion
Primarily excreted by the kidneys.
Half life
Tramadol: approximately 5-7 hours; Paracetamol: approximately 2-3 hours.
Absorption
Both Tramadol and Paracetamol are rapidly and well absorbed after oral administration. Tramadol bioavailability is about 75%, Paracetamol 60-90%.
Metabolism
Both are primarily metabolized in the liver. Tramadol by CYP2D6 and CYP3A4 to O-desmethyltramadol (active) and N-desmethyltramadol. Paracetamol undergoes hepatic glucuronidation and sulfation, and also by CYP2E1.
Side Effects
Contraindications
- Hypersensitivity to Tramadol, Paracetamol, or opioids
- Acute intoxication with alcohol, hypnotics, analgesics, opioids, or psychotropic drugs
- Severe respiratory depression
- Concomitant use of MAO inhibitors or within 14 days of stopping them
- Severe hepatic insufficiency
- Uncontrolled epilepsy
Drug Interactions
Carbamazepine
Decreased Tramadol plasma concentrations.
MAO Inhibitors
Contraindicated due to risk of serotonin syndrome and seizures.
Serotonergic drugs (e.g., SSRIs, SNRIs)
Increased risk of serotonin syndrome.
Warfarin and other coumarin derivatives
Increased INR and bleeding risk.
CNS Depressants (e.g., benzodiazepines, alcohol)
Increased risk of respiratory depression, sedation, coma, and death.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include respiratory depression, seizures, CNS depression, and severe hepatic damage (from paracetamol). Management involves supportive care, naloxone for opioid effects, and N-acetylcysteine for paracetamol overdose.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy unless the potential benefit outweighs the potential risk. Can cause neonatal opioid withdrawal syndrome. Excreted in breast milk, use with caution or avoid during lactation.
Side Effects
Contraindications
- Hypersensitivity to Tramadol, Paracetamol, or opioids
- Acute intoxication with alcohol, hypnotics, analgesics, opioids, or psychotropic drugs
- Severe respiratory depression
- Concomitant use of MAO inhibitors or within 14 days of stopping them
- Severe hepatic insufficiency
- Uncontrolled epilepsy
Drug Interactions
Carbamazepine
Decreased Tramadol plasma concentrations.
MAO Inhibitors
Contraindicated due to risk of serotonin syndrome and seizures.
Serotonergic drugs (e.g., SSRIs, SNRIs)
Increased risk of serotonin syndrome.
Warfarin and other coumarin derivatives
Increased INR and bleeding risk.
CNS Depressants (e.g., benzodiazepines, alcohol)
Increased risk of respiratory depression, sedation, coma, and death.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include respiratory depression, seizures, CNS depression, and severe hepatic damage (from paracetamol). Management involves supportive care, naloxone for opioid effects, and N-acetylcysteine for paracetamol overdose.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy unless the potential benefit outweighs the potential risk. Can cause neonatal opioid withdrawal syndrome. Excreted in breast milk, use with caution or avoid during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by drug regulatory authorities (e.g., DGDA)
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Tramadol/Paracetamol combination in various acute and chronic pain conditions. Studies have shown superior efficacy compared to either drug alone for certain types of pain.
Lab Monitoring
- Liver function tests (especially with prolonged use or high doses)
- Renal function tests (in patients with kidney impairment)
- Monitor respiratory rate and level of consciousness.
- INR for patients on warfarin.
Doctor Notes
- Assess patient's history of substance abuse before prescribing.
- Monitor for signs of respiratory depression, especially during initiation or dose escalation.
- Educate patients on the risks of concomitant use with CNS depressants and alcohol.
- Caution in elderly patients and those with renal/hepatic impairment.
- Consider the potential for serotonin syndrome when co-prescribing with other serotonergic agents.
Patient Guidelines
- Do not exceed the prescribed dose or maximum daily dose.
- Avoid taking other paracetamol-containing products to prevent overdose.
- Do not consume alcohol while on this medication.
- Be cautious when driving or operating machinery due to potential dizziness and somnolence.
- Store out of reach of children.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Utracet can cause dizziness, drowsiness, or blurred vision. Avoid driving or operating heavy machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain adequate hydration.
- For constipation, increase fiber intake and fluid intake.
- Avoid abrupt discontinuation, especially after long-term use, to prevent withdrawal symptoms.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Utracet Brand
Other medicines available under the same brand name
