Utrobin
Generic Name
Dydrogesterone
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| utrobin 10 mg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Utrobin 10 mg Tablet is a synthetic progestogen used in various gynecological conditions like menstrual disorders, endometriosis, and threatened/recurrent miscarriage.
Uses & Indications
Dosage
Adults
For menstrual disorders: 10-20 mg daily from day 11 to day 25 of the cycle. For threatened miscarriage: 40 mg initially, then 10 mg every 8 hours until symptoms subside. For recurrent miscarriage: 10 mg twice daily until the 20th week of pregnancy.
Elderly
No specific dose adjustment is required, but caution is advised due to potential age-related organ function decline.
Renal_impairment
No specific dose adjustments are typically needed, but use with caution in severe renal impairment.
How to Take
Swallow the tablet whole with water, with or without food. Take at the same time each day.
Mechanism of Action
Dydrogesterone acts directly on the uterus, inducing a full secretory endometrium in estrogen-primed uteri, thereby supporting pregnancy and regulating menstrual cycles.
Pharmacokinetics
Onset
Within hours for symptomatic relief; chronic treatment for hormonal regulation.
Excretion
Primarily excreted in the urine (about 60-70%) as metabolites within 72 hours, with some fecal excretion.
Half life
Approximately 5 to 7 hours for dydrogesterone and 14 to 17 hours for its main metabolite.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 0.5 to 2.5 hours.
Metabolism
Extensively metabolized in the liver, primarily to 20α-dihydrodydrogesterone (DHD), which is pharmacologically active.
Side Effects
Contraindications
- Known hypersensitivity to dydrogesterone or any excipients
- Undiagnosed vaginal bleeding
- Known or suspected progestogen-dependent tumor
- Severe liver disease
Drug Interactions
St. John's Wort
May reduce efficacy of dydrogesterone.
Phenytoin, Carbamazepine, Rifampicin
May decrease dydrogesterone levels due to enzyme induction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose is generally well-tolerated and may cause nausea, vomiting, dizziness, and somnolence. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Can be used to support pregnancy in cases of threatened/recurrent miscarriage. Not recommended during breastfeeding as dydrogesterone passes into breast milk.
Side Effects
Contraindications
- Known hypersensitivity to dydrogesterone or any excipients
- Undiagnosed vaginal bleeding
- Known or suspected progestogen-dependent tumor
- Severe liver disease
Drug Interactions
St. John's Wort
May reduce efficacy of dydrogesterone.
Phenytoin, Carbamazepine, Rifampicin
May decrease dydrogesterone levels due to enzyme induction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose is generally well-tolerated and may cause nausea, vomiting, dizziness, and somnolence. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Can be used to support pregnancy in cases of threatened/recurrent miscarriage. Not recommended during breastfeeding as dydrogesterone passes into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of dydrogesterone in its approved indications.
Lab Monitoring
- Regular gynecological examinations
- Liver function tests (in patients with pre-existing liver conditions)
- Blood pressure monitoring
Doctor Notes
- Advise patients on regular follow-ups, especially during pregnancy.
- Consider baseline liver function tests before starting treatment.
Patient Guidelines
- Do not stop taking the medicine abruptly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
- Report any unusual bleeding or side effects immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or somnolence. Avoid driving or operating machinery if you experience these effects.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
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