Vanprox
Generic Name
Pantoprazole 40 mg Suspension
Manufacturer
Hypothetical Pharma Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vanprox 40 mg suspension | ৳ 98.65 | N/A |
Description
Overview of the medicine
Vanprox 40 mg Suspension contains Pantoprazole, a proton pump inhibitor used to reduce stomach acid production. It is prescribed for conditions like acid reflux, heartburn, ulcers, and other gastric acid-related disorders.
Uses & Indications
Dosage
Adults
For GERD/Erosive Esophagitis: 40 mg once daily for up to 8 weeks. For Zollinger-Ellison Syndrome: Dosage varies, usually starting with 80 mg once daily, adjusted based on acid output.
Elderly
No specific dose adjustment is generally required, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with renal impairment.
How to Take
Take the suspension orally, usually once daily, at least 30 minutes before a meal. Shake well before use. Do not crush or chew if it's a different form like tablet.
Mechanism of Action
Pantoprazole irreversibly inhibits the H+/K+-ATPase (proton pump) in the parietal cells of the stomach, thereby blocking the final step of gastric acid secretion.
Pharmacokinetics
Onset
Within 2.5 hours for acid suppression.
Excretion
Mainly excreted renally (approximately 71%) and a smaller amount (approximately 18%) via biliary excretion.
Half life
Approximately 1 hour, but the duration of acid suppression is much longer due to irreversible binding.
Absorption
Rapidly absorbed after oral administration; bioavailability is about 77%. Food may delay absorption but does not affect overall bioavailability.
Metabolism
Extensively metabolized in the liver via the cytochrome P450 (CYP) system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Known hypersensitivity to Pantoprazole or any component of the formulation.
- Hypersensitivity to other substituted benzimidazoles.
Drug Interactions
Clopidogrel
Reduced effectiveness of Clopidogrel (antiplatelet agent).
Methotrexate
May increase Methotrexate levels, especially with high-dose Methotrexate.
Iron Salts, Vitamin B12
Decreased absorption due to reduced gastric acidity.
Ketoconazole, Itraconazole, Erlotinib
Absorption may be decreased due to increased gastric pH.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include drowsiness, tachycardia, nausea, headache. Management is symptomatic and supportive. No specific antidote is known.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Caution is advised during breastfeeding as Pantoprazole is excreted in human milk.
Side Effects
Contraindications
- Known hypersensitivity to Pantoprazole or any component of the formulation.
- Hypersensitivity to other substituted benzimidazoles.
Drug Interactions
Clopidogrel
Reduced effectiveness of Clopidogrel (antiplatelet agent).
Methotrexate
May increase Methotrexate levels, especially with high-dose Methotrexate.
Iron Salts, Vitamin B12
Decreased absorption due to reduced gastric acidity.
Ketoconazole, Itraconazole, Erlotinib
Absorption may be decreased due to increased gastric pH.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include drowsiness, tachycardia, nausea, headache. Management is symptomatic and supportive. No specific antidote is known.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Caution is advised during breastfeeding as Pantoprazole is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unopened). Once opened, use within 28 days.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities for generic Pantoprazole
Patent Status
Off-patent (for generic Pantoprazole)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Pantoprazole in various acid-related disorders. Ongoing research explores its potential in other gastrointestinal conditions.
Lab Monitoring
- For long-term use (over 1 year), periodic monitoring of serum magnesium levels is recommended. Liver function tests may be considered in patients with hepatic impairment.
Doctor Notes
- Assess the necessity of long-term PPI therapy; consider stepping down or discontinuing when appropriate.
- Monitor for potential drug interactions, especially with Clopidogrel and Methotrexate.
- Counsel patients on potential long-term risks such as bone fracture and B12 deficiency, especially in elderly patients or those with pre-existing risk factors.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly without consulting your doctor.
- Report any severe side effects or allergic reactions immediately.
- Do not crush or chew the suspension; shake well before use.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Pantoprazole may cause dizziness or visual disturbances in some patients. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty foods, caffeine, and alcohol.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating; wait at least 2-3 hours.
- Elevate the head of your bed while sleeping.
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