Vasocor
Generic Name
Carvedilol
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vasocor 25 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Vasocor 25 mg Tablet contains Carvedilol, a beta-blocker used to treat high blood pressure, heart failure, and angina. It works by relaxing blood vessels and slowing heart rate, improving blood flow and reducing strain on the heart.
Uses & Indications
Dosage
Adults
For hypertension: Initially 6.25 mg twice daily, increasing to 12.5 mg then 25 mg twice daily. For heart failure: Initially 3.125 mg twice daily, gradually increasing up to 25 mg twice daily (or 50 mg twice daily for patients >85 kg) under medical supervision.
Elderly
No specific dose adjustment for elderly patients with hypertension, but caution is advised in heart failure. Initiate at lower doses and titrate carefully.
Renal_impairment
No dosage adjustment necessary for mild to moderate renal impairment. For severe renal impairment, close monitoring is advised, but specific dose adjustment not usually required.
How to Take
Take orally, with food, to minimize the risk of orthostatic hypotension. Do not crush or chew the tablet.
Mechanism of Action
Carvedilol is a non-selective beta-adrenergic blocker and an alpha1-adrenergic blocker. It reduces peripheral vascular resistance through alpha1-blockade and suppresses the renin-angiotensin-aldosterone system. It also reduces heart rate and myocardial contractility.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 1-2 hours. Therapeutic effect may take several days to weeks to fully manifest, especially in heart failure.
Excretion
Primarily excreted via the bile into the feces (approximately 60-65% of the dose); less than 2% is excreted in urine as unchanged drug.
Half life
Approximately 7-10 hours.
Absorption
Rapidly and extensively absorbed after oral administration, but undergoes significant first-pass metabolism, resulting in an absolute bioavailability of approximately 25% to 35%.
Metabolism
Extensively metabolized in the liver, primarily by aromatic ring oxidation and glucuronidation, mainly by CYP2D6 and CYP2C9.
Side Effects
Contraindications
- •Bronchial asthma or related bronchospastic conditions
- •Second- or third-degree AV block (unless a permanent pacemaker is in place)
- •Sick sinus syndrome (unless a permanent pacemaker is in place)
- •Cardiogenic shock or severe decompensated heart failure requiring IV inotropic therapy
- •Severe bradycardia (heart rate <50 bpm)
- •Severe hepatic impairment
- •Hypersensitivity to Carvedilol or any component of the formulation
Drug Interactions
Digoxin
May increase digoxin concentrations; monitor digoxin levels.
Cimetidine
May increase carvedilol bioavailability.
Rifampicin
May decrease carvedilol plasma concentrations by inducing CYP enzymes.
Insulin or oral hypoglycemic agents
May mask symptoms of hypoglycemia; adjust dosage of hypoglycemic agents.
Calcium channel blockers (e.g., Verapamil, Diltiazem)
Increased risk of AV conduction disturbances and/or heart failure.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe hypotension, bradycardia, cardiac insufficiency, cardiogenic shock, and cardiac arrest. Treatment is symptomatic and supportive, including atropine for bradycardia, glucagon for myocardial depression, and vasopressors for hypotension.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Not recommended during breastfeeding as carvedilol is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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