Veelac
Generic Name
Lactulose
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| veelac 335 gm oral solution | ৳ 144.00 | N/A |
Description
Overview of the medicine
Veelac (Lactulose) is a synthetic disaccharide used to treat chronic constipation and hepatic encephalopathy. It works as an osmotic laxative by drawing water into the colon, softening stools and increasing bowel movements. In hepatic encephalopathy, it reduces ammonia absorption by acidifying the colon content.
Uses & Indications
Dosage
Adults
For constipation: Initially 15-45 ml daily, adjusted according to response. For hepatic encephalopathy: Initially 30-45 ml two to three times daily, adjusted to produce 2-3 soft stools per day.
Elderly
Same as adult dosage, but caution with electrolyte balance for prolonged high doses.
Renal_impairment
No specific dose adjustment required due to minimal systemic absorption.
How to Take
Oral administration. Can be taken directly or mixed with water, fruit juice, or milk. For best results, take at the same time each day.
Mechanism of Action
Lactulose is metabolized by colonic bacteria into low molecular weight organic acids, which acidify the colon content and cause an osmotic effect. This increases stool water content and softens the stool. In hepatic encephalopathy, the acidic environment converts ammonia (NH3) to ammonium (NH4+), which is not readily absorbed, thus reducing blood ammonia levels.
Pharmacokinetics
Onset
Laxative effect: 24-48 hours. Hepatic encephalopathy: may take several days for full effect.
Excretion
Primarily excreted unchanged in feces. Small amounts (less than 3%) excreted in urine.
Half life
Not applicable due to minimal systemic absorption.
Absorption
Minimally absorbed systemically (less than 3%).
Metabolism
Metabolized by colonic bacteria into lactic acid, acetic acid, etc.
Side Effects
Contraindications
- Galactosemia
- Intestinal obstruction
- Acute inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis) if not advised by doctor
- Perforation of the digestive tract or risk of perforation
- Abdominal pain of unknown origin
Drug Interactions
Antacids
May reduce the effect of lactulose by altering colonic pH.
Oral antibiotics
Some broad-spectrum antibiotics may decrease the breakdown of lactulose by gut bacteria, reducing its effectiveness.
Storage
Store below 30°C. Protect from light. Do not freeze or refrigerate as crystallization may occur.
Overdose
Symptoms include abdominal pain, diarrhea, and electrolyte imbalance (especially hypokalemia and hyponatremia). Management involves stopping the drug, symptomatic treatment, and correction of fluid and electrolyte imbalances.
Pregnancy & Lactation
Generally considered safe during pregnancy (Category B) and lactation due to minimal systemic absorption. Consult a doctor before use.
Side Effects
Contraindications
- Galactosemia
- Intestinal obstruction
- Acute inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis) if not advised by doctor
- Perforation of the digestive tract or risk of perforation
- Abdominal pain of unknown origin
Drug Interactions
Antacids
May reduce the effect of lactulose by altering colonic pH.
Oral antibiotics
Some broad-spectrum antibiotics may decrease the breakdown of lactulose by gut bacteria, reducing its effectiveness.
Storage
Store below 30°C. Protect from light. Do not freeze or refrigerate as crystallization may occur.
Overdose
Symptoms include abdominal pain, diarrhea, and electrolyte imbalance (especially hypokalemia and hyponatremia). Management involves stopping the drug, symptomatic treatment, and correction of fluid and electrolyte imbalances.
Pregnancy & Lactation
Generally considered safe during pregnancy (Category B) and lactation due to minimal systemic absorption. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Widely approved globally
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Lactulose has been subject to numerous clinical trials confirming its efficacy and safety for chronic constipation and hepatic encephalopathy.
Lab Monitoring
- Electrolyte levels (especially potassium, sodium) with prolonged high-dose use or significant diarrhea. Blood ammonia levels for hepatic encephalopathy.
Doctor Notes
- Advise patients to maintain adequate hydration.
- Monitor electrolyte levels in patients on prolonged high-dose therapy.
- Educate patients on the delayed onset of action for laxative effect.
Patient Guidelines
- Drink plenty of fluids while taking this medicine.
- It may take 2-3 days for the full laxative effect to occur.
- Do not use for more than 7 days for constipation without consulting a doctor.
- Report any severe abdominal pain or persistent diarrhea to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Veelac is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a high-fiber diet.
- Ensure adequate daily fluid intake.
- Engage in regular physical activity to promote bowel regularity.
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Global Brand Names
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