Ventus
Generic Name
Loratadine
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ventus 10 mg tablet | ৳ 11.00 | ৳ 110.00 |
Description
Overview of the medicine
Ventus 10 mg Tablet contains Loratadine, a non-drowsy antihistamine used to relieve symptoms associated with allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives). It helps alleviate sneezing, runny nose, itchy or watery eyes, and itchy skin rashes.
Uses & Indications
Dosage
Adults
10 mg once daily.
Elderly
No dosage adjustment necessary.
Renal_impairment
For patients with severe renal impairment (creatinine clearance < 30 mL/min), initial dose of 10 mg every other day is recommended.
How to Take
Ventus 10 mg tablet should be taken orally, with or without food. It can be swallowed whole with water.
Mechanism of Action
Loratadine is a tricyclic antihistamine with selective peripheral H1-receptor antagonist activity. It prevents histamine from binding to H1 receptors, thereby blocking the symptoms associated with the allergic response, such as itching, sneezing, and vasodilation, with minimal sedative and anticholinergic effects.
Pharmacokinetics
Onset
Within 1-3 hours
Excretion
Approximately 40% excreted in urine and 42% in feces over a 10-day period, primarily as metabolites.
Half life
Loratadine: 8.4 hours (range 3-20 hours); Descarboethoxyloratadine (active metabolite): 18.2 hours (range 8.8-92 hours)
Absorption
Rapidly and well absorbed from the gastrointestinal tract. Peak plasma concentrations are reached in 1-1.5 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (CYP3A4 and CYP2D6) to its major active metabolite, descarboethoxyloratadine.
Side Effects
Contraindications
- Hypersensitivity to loratadine or any component of the formulation.
- Children under 2 years of age.
Drug Interactions
Alcohol
No potentiation of alcohol effects has been found.
Cimetidine
May increase plasma concentrations of loratadine and its active metabolite.
Erythromycin
May increase plasma concentrations of loratadine and its active metabolite.
Ketoconazole
May increase plasma concentrations of loratadine and its active metabolite.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, tachycardia, and headache. Management should be symptomatic and supportive. Gastric lavage and activated charcoal may be considered. Loratadine is not effectively removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. Should be used during pregnancy only if clearly needed. Loratadine and its active metabolite are excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to loratadine or any component of the formulation.
- Children under 2 years of age.
Drug Interactions
Alcohol
No potentiation of alcohol effects has been found.
Cimetidine
May increase plasma concentrations of loratadine and its active metabolite.
Erythromycin
May increase plasma concentrations of loratadine and its active metabolite.
Ketoconazole
May increase plasma concentrations of loratadine and its active metabolite.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, tachycardia, and headache. Management should be symptomatic and supportive. Gastric lavage and activated charcoal may be considered. Loratadine is not effectively removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. Should be used during pregnancy only if clearly needed. Loratadine and its active metabolite are excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, consult the packaging for exact expiry.
Availability
Pharmacies, drug stores
Approval Status
Approved by major regulatory bodies globally
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Loratadine has undergone extensive clinical trials demonstrating its efficacy and safety for allergic rhinitis and chronic idiopathic urticaria. These trials established its non-sedating profile compared to first-generation antihistamines.
Lab Monitoring
- Generally not required for routine use. Liver function tests may be considered in patients with hepatic impairment.
Doctor Notes
- Loratadine is a preferred second-generation antihistamine due to its non-sedating nature.
- Consider alternative antihistamines if no relief or adverse effects are noted.
- Advise patients on proper administration and potential mild side effects.
Patient Guidelines
- Take exactly as directed by your doctor or pharmacist.
- Do not exceed the recommended dose.
- Inform your doctor if symptoms do not improve or worsen.
- Avoid alcohol, although no potentiation has been found, as it may enhance sedation from other sources.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Although Ventus is generally non-drowsy, some individuals may experience drowsiness. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Identify and avoid known allergens where possible.
- Maintain a clean environment at home to minimize exposure to dust mites and pet dander.
- Consult a healthcare professional for chronic or severe allergies.
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