Veri Kit
Generic Name
Mifepristone + Misoprostol
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| veri kit 200 mg tablet | ৳ 300.00 | N/A |
Description
Overview of the medicine
Veri Kit is a combination medicine containing Mifepristone and Misoprostol, used for medical termination of intrauterine pregnancy up to 63 days of gestation (9 weeks).
Uses & Indications
Dosage
Adults
Day 1: 1 tablet Mifepristone 200 mg orally. Day 3 (24-48 hours later): 4 tablets Misoprostol 200 mcg (total 800 mcg) buccally (inside the cheek) or vaginally.
Elderly
Not typically indicated for elderly population.
Renal_impairment
No specific dose adjustment recommendations, use with caution.
How to Take
Mifepristone is taken orally with water. Misoprostol tablets are placed buccally (2 tablets in each cheek pouch) and allowed to dissolve for 30 minutes, then remaining fragments are swallowed with water, or placed vaginally.
Mechanism of Action
Mifepristone works by blocking the effects of progesterone, a hormone necessary for maintaining pregnancy. This leads to the shedding of the uterine lining and softening of the cervix. Misoprostol, a prostaglandin analogue, causes uterine contractions, which helps to expel the uterine contents.
Pharmacokinetics
Onset
Uterine bleeding usually begins within 24-72 hours after Misoprostol administration.
Excretion
Mifepristone: Primarily fecal (83%), with some renal (9%). Misoprostol acid: Primarily renal (about 73%).
Half life
Mifepristone: About 18-39 hours for total drug and metabolites. Misoprostol acid: About 20-40 minutes.
Absorption
Mifepristone: Rapidly absorbed, peak plasma concentration reached in 1-2 hours. Misoprostol: Rapidly absorbed and de-esterified to its active metabolite (misoprostol acid), peak plasma concentration of metabolite reached in about 15-30 minutes.
Metabolism
Mifepristone: Extensive hepatic metabolism via CYP3A4. Misoprostol: Rapidly metabolized to its active free acid.
Side Effects
Contraindications
- Confirmed or suspected ectopic pregnancy
- Known hypersensitivity to Mifepristone or Misoprostol
- Chronic adrenal failure
- Uncontrolled asthma
- Hemorrhagic disorders or concomitant anticoagulant therapy
- Inherited porphyria
- Known IUD in place
Drug Interactions
NSAIDs
May reduce the effect of Misoprostol by inhibiting prostaglandin synthesis.
CYP3A4 inducers
Rifampicin, Dexamethasone, Phenytoin, Phenobarbital, Carbamazepine, St. John’s Wort may decrease Mifepristone levels.
CYP3A4 inhibitors
Ketoconazole, Itraconazole, Erythromycin, Grapefruit juice may increase Mifepristone levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of Mifepristone overdose may include adrenal insufficiency. Misoprostol overdose may cause abdominal pain, nausea, vomiting, diarrhea, tremors, fever, phlebitis, bradycardia, or hypotension. Management is symptomatic and supportive.
Pregnancy & Lactation
Veri Kit is intended for medical termination of pregnancy. It should not be used in ongoing pregnancies unless for termination. Mifepristone and its metabolites are excreted in breast milk; therefore, breastfeeding should be avoided for several days after treatment.
Side Effects
Contraindications
- Confirmed or suspected ectopic pregnancy
- Known hypersensitivity to Mifepristone or Misoprostol
- Chronic adrenal failure
- Uncontrolled asthma
- Hemorrhagic disorders or concomitant anticoagulant therapy
- Inherited porphyria
- Known IUD in place
Drug Interactions
NSAIDs
May reduce the effect of Misoprostol by inhibiting prostaglandin synthesis.
CYP3A4 inducers
Rifampicin, Dexamethasone, Phenytoin, Phenobarbital, Carbamazepine, St. John’s Wort may decrease Mifepristone levels.
CYP3A4 inhibitors
Ketoconazole, Itraconazole, Erythromycin, Grapefruit juice may increase Mifepristone levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of Mifepristone overdose may include adrenal insufficiency. Misoprostol overdose may cause abdominal pain, nausea, vomiting, diarrhea, tremors, fever, phlebitis, bradycardia, or hypotension. Management is symptomatic and supportive.
Pregnancy & Lactation
Veri Kit is intended for medical termination of pregnancy. It should not be used in ongoing pregnancies unless for termination. Mifepristone and its metabolites are excreted in breast milk; therefore, breastfeeding should be avoided for several days after treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Hospitals, Clinics, Pharmacies (with prescription)
Approval Status
DGDA approved
Patent Status
Generic versions available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the safety and efficacy of Mifepristone and Misoprostol for medical abortion.
Lab Monitoring
- Confirmation of complete abortion via ultrasound 14-21 days after administration.
- Hemoglobin levels if significant bleeding occurs.
Doctor Notes
- Confirm intrauterine pregnancy and gestational age before administration.
- Counsel patients thoroughly on the procedure, expected events, and potential complications.
- Ensure a follow-up visit to confirm complete abortion.
Patient Guidelines
- Understand the complete process and expected side effects.
- Follow up with your healthcare provider as instructed.
- Seek immediate medical attention for fever, severe pain, or prolonged heavy bleeding.
Missed Dose Advice
This is a single-use regimen. Follow the exact instructions provided by the healthcare provider. Missing or altering doses can affect efficacy and safety.
Driving Precautions
May cause dizziness or fatigue; avoid driving or operating heavy machinery until you know how you react to the medicine.
Lifestyle Advice
- Rest for a few days after the procedure.
- Avoid strenuous activities.
- Avoid inserting anything into the vagina (e.g., tampons, douching) until bleeding stops.
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International brand names for this medicine. Click a brand to search for detailed information.