Verigra
Generic Name
Sildenafil Citrate
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| verigra 100 mg tablet | ৳ 40.00 | ৳ 160.00 |
Description
Overview of the medicine
Verigra (Sildenafil Citrate) is a medication used to treat erectile dysfunction (ED) in men. It helps achieve and maintain an erection sufficient for sexual activity by increasing blood flow to the penis.
Uses & Indications
Dosage
Adults
For most patients, the recommended dose is 50 mg taken approximately 1 hour before sexual activity. Based on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day.
Elderly
No specific dose adjustment is required for elderly patients (≥65 years) if liver and kidney function are normal. However, a starting dose of 25 mg may be considered due to age-related decrease in clearance.
Renal_impairment
For patients with severe renal impairment (creatinine clearance <30 mL/min), a starting dose of 25 mg should be considered.
How to Take
Verigra is taken orally, with or without food. However, a high-fat meal may delay the effect. For optimal effect, it is usually taken on an empty stomach approximately 1 hour before sexual activity.
Mechanism of Action
Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum, where PDE5 is responsible for degradation of cGMP. Sildenafil enhances the effect of nitric oxide by inhibiting PDE5, resulting in increased levels of cGMP, smooth muscle relaxation, and increased blood flow into the corpus cavernosum, thus facilitating an erection.
Pharmacokinetics
Onset
Approximately 30-60 minutes.
Excretion
Eliminated predominantly as metabolites in the feces (approximately 80% of the administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose).
Half life
Approximately 3-5 hours.
Absorption
Rapidly absorbed after oral administration, with mean absolute bioavailability of 41%. Peak plasma concentrations (Cmax) are reached within 30-120 minutes (median 60 minutes) of oral dosing in the fasted state.
Metabolism
Primarily metabolized by hepatic microsomal isoenzymes CYP3A4 (major route) and CYP2C9 (minor route). The major circulating metabolite, N-desmethyl sildenafil, is about 50% as potent as the parent drug.
Side Effects
Contraindications
- Concomitant use with nitrates (e.g., nitroglycerin) or nitric oxide donors due to potentiation of hypotensive effects.
- Hypersensitivity to sildenafil or any component of the tablet.
- Patients for whom sexual activity is inadvisable due to cardiovascular status.
- Recent history of myocardial infarction, stroke, or life-threatening arrhythmia.
- Known hereditary degenerative retinal disorders, such as retinitis pigmentosa.
Drug Interactions
Nitrates
Potentiation of hypotensive effects, leading to severe hypotension.
Riociguat
Concomitant use is contraindicated due to risk of severe hypotension.
Alpha-blockers (e.g., doxazosin, tamsulosin)
Risk of symptomatic hypotension, especially if taken within 4 hours.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir)
Increases sildenafil plasma levels, requiring dose reduction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In studies with healthy volunteers, doses up to 800 mg resulted in similar adverse events as seen at lower doses, but with increased incidence and severity. In cases of overdose, standard supportive measures should be adopted as sildenafil is highly protein-bound and not expected to be eliminated by renal dialysis.
Pregnancy & Lactation
Verigra is not indicated for use in women. Animal studies did not indicate direct or indirect harmful effects with respect to pregnancy or embryo/fetal development.
Side Effects
Contraindications
- Concomitant use with nitrates (e.g., nitroglycerin) or nitric oxide donors due to potentiation of hypotensive effects.
- Hypersensitivity to sildenafil or any component of the tablet.
- Patients for whom sexual activity is inadvisable due to cardiovascular status.
- Recent history of myocardial infarction, stroke, or life-threatening arrhythmia.
- Known hereditary degenerative retinal disorders, such as retinitis pigmentosa.
Drug Interactions
Nitrates
Potentiation of hypotensive effects, leading to severe hypotension.
Riociguat
Concomitant use is contraindicated due to risk of severe hypotension.
Alpha-blockers (e.g., doxazosin, tamsulosin)
Risk of symptomatic hypotension, especially if taken within 4 hours.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir)
Increases sildenafil plasma levels, requiring dose reduction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In studies with healthy volunteers, doses up to 800 mg resulted in similar adverse events as seen at lower doses, but with increased incidence and severity. In cases of overdose, standard supportive measures should be adopted as sildenafil is highly protein-bound and not expected to be eliminated by renal dialysis.
Pregnancy & Lactation
Verigra is not indicated for use in women. Animal studies did not indicate direct or indirect harmful effects with respect to pregnancy or embryo/fetal development.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available, original patent expired
Clinical Trials
Sildenafil has been extensively studied in numerous clinical trials involving thousands of men with erectile dysfunction, demonstrating significant efficacy and a generally well-tolerated safety profile.
Lab Monitoring
- Routine laboratory monitoring is generally not required for patients taking Verigra for erectile dysfunction. However, baseline cardiovascular assessment is recommended before starting treatment.
Doctor Notes
- Thorough medical history and physical examination should be conducted to diagnose erectile dysfunction and determine potential underlying causes before considering Verigra.
- Counsel patients on the proper use of Verigra and potential side effects, particularly priapism and sudden visual/hearing changes.
- Assess cardiovascular risk factors before prescribing, as sexual activity itself poses a cardiac risk.
Patient Guidelines
- Take Verigra exactly as prescribed by your doctor.
- Do not take more than one dose in a 24-hour period.
- Seek immediate medical attention if an erection lasts longer than 4 hours (priapism).
- Inform your doctor about all other medications you are taking, especially nitrates.
Missed Dose Advice
Verigra is taken on an as-needed basis for erectile dysfunction. There is no regular dosing schedule. Do not take more than one dose per day.
Driving Precautions
Verigra may cause dizziness or visual disturbances. Patients should be aware of how they react to Verigra before driving or operating machinery.
Lifestyle Advice
- Maintain a healthy lifestyle, including regular exercise and a balanced diet, which can improve overall sexual health.
- Limit alcohol intake, as excessive alcohol can worsen erectile dysfunction and increase side effects.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Verigra Brand
Other medicines available under the same brand name
