Veslac
Generic Name
Fesoterodine Fumarate
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| veslac 10 mg tablet | ৳ 10.30 | N/A |
Description
Overview of the medicine
Veslac (Fesoterodine Fumarate) is an extended-release tablet used to treat symptoms of overactive bladder (OAB), such as urge urinary incontinence, urgency, and urinary frequency.
Uses & Indications
Dosage
Adults
Recommended starting dose is 4 mg orally once daily. May be increased to 8 mg once daily based on individual response and tolerability.
Elderly
No dose adjustment is generally required for elderly patients, but caution is advised.
Renal_impairment
For severe renal impairment (CrCl <30 mL/min), the maximum dose is 4 mg once daily. For moderate impairment (CrCl 30-80 mL/min), caution is advised, and max 8 mg.
How to Take
Take orally once daily with or without food. Swallow the tablet whole; do not chew, crush, or divide it.
Mechanism of Action
Fesoterodine is a prodrug that is rapidly and extensively hydrolyzed by plasma esterases to its active metabolite, 5-hydroxymethyltolterodine (5-HMT). 5-HMT is a muscarinic receptor antagonist that blocks muscarinic receptors in the bladder, thereby inhibiting involuntary detrusor contractions.
Pharmacokinetics
Onset
Clinical effects may be observed within a few weeks.
Excretion
Primarily excreted via the kidneys (approximately 70% as 5-HMT and its metabolites) and to a lesser extent via feces (approximately 10%).
Half life
Approximately 7 hours for 5-HMT.
Absorption
Fesoterodine is rapidly absorbed and extensively hydrolyzed to its active metabolite, 5-HMT. Peak plasma concentrations of 5-HMT are reached within approximately 5 hours.
Metabolism
Rapid and extensive hydrolysis by plasma esterases to 5-HMT. Further metabolism of 5-HMT occurs via CYP2D6 and CYP3A4.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Myasthenia gravis
- Severe hepatic impairment
- Known hypersensitivity to fesoterodine or any component of the tablet
Drug Interactions
CYP2D6 inhibitors
May slightly increase exposure to 5-HMT, but no dose adjustment usually needed.
Anticholinergic drugs
May enhance anticholinergic effects, increasing risk of dry mouth, constipation, etc.
Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
Increase exposure to 5-HMT. Max dose 4 mg if co-administered.
Drugs metabolized by CYP2D6 (e.g., flecainide, metoprolol)
No significant interaction observed.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe anticholinergic effects (e.g., severe dry mouth, blurred vision, flushed hot skin, tachycardia, urinary retention, dilated pupils). Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered. Physostigmine may be used for severe central anticholinergic effects.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is not known whether fesoterodine is excreted in human milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Myasthenia gravis
- Severe hepatic impairment
- Known hypersensitivity to fesoterodine or any component of the tablet
Drug Interactions
CYP2D6 inhibitors
May slightly increase exposure to 5-HMT, but no dose adjustment usually needed.
Anticholinergic drugs
May enhance anticholinergic effects, increasing risk of dry mouth, constipation, etc.
Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
Increase exposure to 5-HMT. Max dose 4 mg if co-administered.
Drugs metabolized by CYP2D6 (e.g., flecainide, metoprolol)
No significant interaction observed.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe anticholinergic effects (e.g., severe dry mouth, blurred vision, flushed hot skin, tachycardia, urinary retention, dilated pupils). Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered. Physostigmine may be used for severe central anticholinergic effects.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is not known whether fesoterodine is excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date. Refer to the specific product packaging.
Availability
Available in pharmacies nationwide
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic versions available, original compound may be off-patent
Clinical Trials
Fesoterodine has undergone several large-scale clinical trials demonstrating its efficacy and safety in treating OAB symptoms.
Lab Monitoring
- No specific routine lab monitoring is required for fesoterodine. Renal and hepatic function should be assessed before initiating treatment and periodically thereafter in patients with known impairment.
Doctor Notes
- Counsel patients on potential anticholinergic side effects, especially dry mouth and constipation.
- Consider dose adjustment in patients with severe renal impairment or those taking strong CYP3A4 inhibitors.
- Emphasize the importance of taking the extended-release tablet whole.
- Monitor for signs of urinary retention.
Patient Guidelines
- Take the tablet whole, do not chew or crush it.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause blurred vision, dizziness, or drowsiness. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid excessive caffeine and alcohol intake, as these can irritate the bladder.
- Maintain a healthy weight.
- Practice bladder training techniques.
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