Vesotan
Generic Name
Solifenacin Succinate
Manufacturer
Drug International Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vesotan 8 mg tablet | ৳ 6.02 | ৳ 60.20 |
| vesotan 16 mg tablet | ৳ 11.03 | ৳ 110.30 |
Description
Overview of the medicine
Vesotan contains Solifenacin Succinate, an antimuscarinic agent used for the symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency as may occur in adult patients with overactive bladder (OAB) syndrome.
Uses & Indications
Dosage
Adults
Initial dose 5 mg once daily. May be increased to 10 mg once daily based on efficacy and tolerability. Take with or without food.
Elderly
No dose adjustment required, but caution is advised.
Renal_impairment
Maximum 5 mg once daily for severe renal impairment (CrCl <30 mL/min). No dose adjustment for mild to moderate impairment.
How to Take
Swallow the tablet whole with liquid. Do not chew, crush, or break. Can be taken with or without food.
Mechanism of Action
Solifenacin is a competitive muscarinic receptor antagonist. It works by blocking muscarinic receptors (primarily M3 receptors) in the bladder, which reduces involuntary bladder muscle contractions, thereby increasing bladder capacity and decreasing the symptoms of OAB.
Pharmacokinetics
Onset
Clinical effects seen within a week, full effect in 2-4 weeks.
Excretion
Excreted in urine (approx. 70%) and feces (approx. 23%) as metabolites and unchanged drug.
Half life
Approximately 45-68 hours.
Absorption
Well absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 3 to 8 hours.
Metabolism
Extensively metabolized by the liver, primarily by CYP3A4.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Severe liver impairment (Child-Pugh Class C)
- Hypersensitivity to the active substance or any excipient.
Drug Interactions
Cholinergic agonists
May reduce the effect of Solifenacin.
Other antimuscarinic agents
Enhanced therapeutic effect and increased risk of side effects.
Drugs that prolong QT interval
Use with caution due to potential for QT prolongation.
Potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
Maximum daily dose of Solifenacin should not exceed 5 mg when co-administered.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include severe anticholinergic effects (e.g., severe dry mouth, blurred vision, tachycardia, urinary retention). Treatment is supportive, potentially requiring gastric lavage, activated charcoal, and in severe cases, physostigmine.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Excretion into breast milk is unknown, use with caution.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Severe liver impairment (Child-Pugh Class C)
- Hypersensitivity to the active substance or any excipient.
Drug Interactions
Cholinergic agonists
May reduce the effect of Solifenacin.
Other antimuscarinic agents
Enhanced therapeutic effect and increased risk of side effects.
Drugs that prolong QT interval
Use with caution due to potential for QT prolongation.
Potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
Maximum daily dose of Solifenacin should not exceed 5 mg when co-administered.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include severe anticholinergic effects (e.g., severe dry mouth, blurred vision, tachycardia, urinary retention). Treatment is supportive, potentially requiring gastric lavage, activated charcoal, and in severe cases, physostigmine.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Excretion into breast milk is unknown, use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA (Bangladesh), FDA (USA)
Patent Status
Generic versions available, original patent expired
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in OAB patients, including studies like the VENUS trial program.
Lab Monitoring
- Monitor renal function (especially in severe renal impairment) and liver function (in moderate hepatic impairment).
Doctor Notes
- Counsel patients on anticholinergic side effects, particularly dry mouth and constipation.
- Assess for pre-existing conditions that may be exacerbated by anticholinergic agents.
- Start with the lowest effective dose.
Patient Guidelines
- Take exactly as prescribed.
- Do not stop taking the medicine without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause blurred vision, somnolence, or dizziness. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid excessive caffeine or alcohol, which can irritate the bladder.
- Practice bladder training techniques if recommended by your doctor.
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Global Brand Names
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