Vestar MR
Generic Name
Trimetazidine Dihydrochloride (Modified Release)
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vestar mr 35 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Vestar MR is a cardioprotective agent used for the symptomatic treatment of stable angina pectoris in adults, particularly in patients who are intolerant to or inadequately controlled by first-line antianginal therapies.
Uses & Indications
Dosage
Adults
One 35 mg modified-release tablet twice daily, i.e., once in the morning and once in the evening, during meals.
Elderly
No specific dose adjustment is required in elderly patients. However, caution should be exercised in elderly patients with moderate renal impairment.
Renal_impairment
For patients with moderate renal impairment (creatinine clearance 30-60 ml/min), the recommended dose is one 35 mg modified-release tablet in the morning during breakfast. Severe renal impairment (creatinine clearance < 30 ml/min) is a contraindication.
How to Take
Vestar MR tablets should be taken orally, with meals, and swallowed whole with a glass of water. Do not chew or crush the tablet.
Mechanism of Action
Trimetazidine inhibits the 3-ketoacyl CoA thiolase enzyme in the myocardium, shifting the energy metabolism from fatty acid oxidation to glucose oxidation. This change in metabolism optimizes myocardial energy processes during ischemia and protects cells from the effects of reduced oxygen supply.
Pharmacokinetics
Onset
Gradual onset of anti-ischemic effect, typically within a few days of regular administration.
Excretion
Primarily excreted unchanged in the urine (approximately 80% of the dose).
Half life
Plasma half-life of approximately 7 hours for the modified-release formulation.
Absorption
Rapid absorption after oral administration; peak plasma concentration approximately 2 hours for modified-release formulation.
Metabolism
Minor hepatic metabolism; no major active metabolites identified.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Parkinson's disease, Parkinsonian symptoms, tremors, restless leg syndrome, and other related movement disorders.
- Severe renal impairment (creatinine clearance < 30 ml/min).
Drug Interactions
0
No clinically significant drug interactions have been reported with Trimetazidine.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited data on Trimetazidine overdose. Symptomatic treatment should be provided.
Pregnancy & Lactation
The use of Trimetazidine during pregnancy is not recommended due to limited data. It is not known whether Trimetazidine is excreted in human milk, therefore, breastfeeding is not recommended during treatment.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Parkinson's disease, Parkinsonian symptoms, tremors, restless leg syndrome, and other related movement disorders.
- Severe renal impairment (creatinine clearance < 30 ml/min).
Drug Interactions
0
No clinically significant drug interactions have been reported with Trimetazidine.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited data on Trimetazidine overdose. Symptomatic treatment should be provided.
Pregnancy & Lactation
The use of Trimetazidine during pregnancy is not recommended due to limited data. It is not known whether Trimetazidine is excreted in human milk, therefore, breastfeeding is not recommended during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Available in pharmacies across Bangladesh
Approval Status
Approved for use in Bangladesh
Patent Status
Off-patent, generic available
Clinical Trials
Extensive clinical trials have demonstrated Trimetazidine's efficacy in reducing angina attacks and improving exercise tolerance in patients with stable angina.
Lab Monitoring
- No specific routine lab monitoring is required.
Doctor Notes
- Monitor patients for signs of Parkinsonian symptoms, especially in the elderly and those with renal impairment. If movement disorders develop, discontinue treatment.
- Dose adjustment required in moderate renal impairment.
Patient Guidelines
- Take the medication exactly as prescribed by your doctor.
- Do not stop taking the medication without consulting your doctor.
- Swallow the tablet whole with water, do not chew or crush it.
- Inform your doctor about any new or worsening symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness and disturbed vision, which might affect your ability to drive or operate machinery. Exercise caution until you know how Trimetazidine affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid smoking and excessive alcohol consumption.
- Manage stress effectively to improve heart health.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.