Viagrazen
Generic Name
Sildenafil Citrate
Manufacturer
Reputed Pharmaceutical Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| viagrazen 50 mg tablet | ৳ 25.00 | ৳ 150.00 |
Description
Overview of the medicine
Viagrazen 50 mg Tablet contains Sildenafil Citrate, a phosphodiesterase-5 (PDE5) inhibitor. It is primarily used to treat erectile dysfunction (impotence) in men by increasing blood flow to the penis during sexual stimulation. It helps achieve and maintain an erection.
Uses & Indications
Dosage
Adults
The recommended dose is 50 mg taken approximately one hour before sexual activity. Based on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg. The maximum recommended dose is 100 mg once daily.
Elderly
No dosage adjustment is generally required for elderly patients, but a starting dose of 25 mg should be considered due to potential age-related decline in renal and hepatic function.
Renal_impairment
For patients with severe renal impairment (creatinine clearance <30 mL/min), a starting dose of 25 mg should be considered.
How to Take
Take the tablet orally with water, approximately one hour before planned sexual activity. It can be taken with or without food, but a high-fat meal may delay the onset of action. Do not take more than one dose per day.
Mechanism of Action
Sildenafil inhibits phosphodiesterase type 5 (PDE5), an enzyme responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. By inhibiting PDE5, Sildenafil increases cGMP levels, leading to smooth muscle relaxation and increased blood flow into the penis during sexual stimulation, thus facilitating an erection.
Pharmacokinetics
Onset
Typically within 30-60 minutes.
Excretion
Excreted predominantly as metabolites in the feces (approximately 80% of the administered oral dose) and, to a lesser extent, in the urine (approximately 13% of the administered oral dose).
Half life
Approximately 3-5 hours.
Absorption
Rapidly absorbed. Mean absolute bioavailability is about 41%. Peak plasma concentrations are reached within 30-120 minutes (median 60 minutes) of oral dosing in the fasted state.
Metabolism
Primarily metabolized by CYP3A4 (major route) and CYP2C9 (minor route) in the liver. The major circulating metabolite, N-desmethyl sildenafil, has about 50% of the activity of sildenafil.
Side Effects
Contraindications
- Concomitant use of nitrates in any form (e.g., nitroglycerin, isosorbide dinitrate) due to the risk of severe hypotension.
- Concomitant use of guanylate cyclase stimulators (e.g., riociguat).
- Patients with known hypersensitivity to Sildenafil or any component of the tablet.
- Patients for whom sexual activity is inadvisable due to underlying cardiovascular conditions.
- Recent stroke, myocardial infarction, or life-threatening arrhythmia.
- Severe hepatic impairment.
- Known hereditary degenerative retinal disorders (e.g., retinitis pigmentosa).
- Loss of vision in one eye due to non-arteritic anterior ischemic optic neuropathy (NAION).
Drug Interactions
Alcohol
Excessive alcohol consumption may increase the risk of orthostatic hypotension.
Nitrates
Potentiation of hypotensive effects; concomitant use is contraindicated.
Riociguat
Concomitant use is contraindicated due to increased risk of hypotension.
Alpha-blockers
Potential for symptomatic hypotension. Initiate Sildenafil at 25 mg in patients on alpha-blocker therapy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir, Erythromycin)
Can significantly increase Sildenafil plasma levels. A starting dose of 25 mg should be considered in these patients.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In studies with healthy volunteers, single doses up to 800 mg have been given. Adverse reactions were similar to those seen at lower doses but generally increased in incidence and severity. In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and not eliminated in the urine.
Pregnancy & Lactation
Viagrazen is not indicated for use in women. There are no adequate and well-controlled studies of Sildenafil in pregnant or lactating women.
Side Effects
Contraindications
- Concomitant use of nitrates in any form (e.g., nitroglycerin, isosorbide dinitrate) due to the risk of severe hypotension.
- Concomitant use of guanylate cyclase stimulators (e.g., riociguat).
- Patients with known hypersensitivity to Sildenafil or any component of the tablet.
- Patients for whom sexual activity is inadvisable due to underlying cardiovascular conditions.
- Recent stroke, myocardial infarction, or life-threatening arrhythmia.
- Severe hepatic impairment.
- Known hereditary degenerative retinal disorders (e.g., retinitis pigmentosa).
- Loss of vision in one eye due to non-arteritic anterior ischemic optic neuropathy (NAION).
Drug Interactions
Alcohol
Excessive alcohol consumption may increase the risk of orthostatic hypotension.
Nitrates
Potentiation of hypotensive effects; concomitant use is contraindicated.
Riociguat
Concomitant use is contraindicated due to increased risk of hypotension.
Alpha-blockers
Potential for symptomatic hypotension. Initiate Sildenafil at 25 mg in patients on alpha-blocker therapy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir, Erythromycin)
Can significantly increase Sildenafil plasma levels. A starting dose of 25 mg should be considered in these patients.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In studies with healthy volunteers, single doses up to 800 mg have been given. Adverse reactions were similar to those seen at lower doses but generally increased in incidence and severity. In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and not eliminated in the urine.
Pregnancy & Lactation
Viagrazen is not indicated for use in women. There are no adequate and well-controlled studies of Sildenafil in pregnant or lactating women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Sildenafil has been extensively studied in numerous clinical trials for its efficacy and safety in treating erectile dysfunction across various patient populations.
Lab Monitoring
- No specific routine lab monitoring is required for Sildenafil use in erectile dysfunction. However, patients with underlying cardiovascular risk factors may require monitoring of those conditions.
Doctor Notes
- Thorough cardiovascular assessment is crucial before prescribing Sildenafil, especially in patients with pre-existing cardiac conditions.
- Educate patients on the proper administration, potential interactions (especially with nitrates), and warning signs of serious side effects like priapism or sudden sensory loss.
- Consider starting with a lower dose (25 mg) in elderly patients, those with severe renal or hepatic impairment, or those on potent CYP3A4 inhibitors.
Patient Guidelines
- Take Viagrazen approximately one hour before sexual activity, not more than once daily.
- Do not take this medicine if you are also taking nitrate medications (e.g., nitroglycerin) for chest pain, as this combination can cause a dangerous drop in blood pressure.
- Seek immediate medical attention if you experience a sudden loss of vision or hearing, or if you have an erection lasting longer than 4 hours (priapism).
- Inform your doctor about all other medications you are taking, especially alpha-blockers, to avoid potential drug interactions.
Missed Dose Advice
Viagrazen is taken as needed, so you are unlikely to miss a dose. Do not take extra doses to make up for a missed one.
Driving Precautions
Viagrazen may cause dizziness or visual disturbances (e.g., blurred vision). Patients should be aware of how they react to this medication before driving or operating machinery.
Lifestyle Advice
- Maintain a healthy lifestyle, including regular exercise and a balanced diet, which can improve overall cardiovascular health and potentially aid in managing ED.
- Avoid excessive alcohol consumption, as it can worsen ED and increase the risk of certain side effects.
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