Viera
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
viera 200 mg suspension | ৳ 1,000.00 | N/A |
Description
Overview of the medicine
Viera 200 mg Suspension contains Cefixime, a third-generation cephalosporin antibiotic used to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, otitis media, and gonorrhoea. It works by preventing the growth of bacteria.
Uses & Indications
Dosage
Adults
200 mg twice daily or 400 mg once daily, for 7 to 14 days, depending on the infection severity and type.
Elderly
No dosage adjustment is generally necessary in elderly patients unless there is severe renal impairment.
Renal_impairment
For creatinine clearance <30 ml/min, the dosage should be reduced to 200 mg once daily. For hemodialysis or CAPD, 200 mg once daily.
How to Take
Viera 200 mg Suspension should be taken orally, with or without food. Shake the bottle well before each use. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby interfering with the transpeptidation process during peptidoglycan synthesis, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved 2 to 6 hours after oral administration.
Excretion
Approximately 50% of an absorbed dose is excreted unchanged in the urine over 24 hours. Some biliary excretion also occurs.
Half life
Plasma elimination half-life averages 3 to 4 hours in healthy individuals.
Absorption
Approximately 40-50% absorbed orally, food may delay absorption but not significantly affect extent.
Metabolism
Cefixime is not extensively metabolized; no active metabolites have been identified.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or to other cephalosporin antibiotics.
- History of severe hypersensitivity reaction to any penicillin.
Drug Interactions
Warfarin
May increase prothrombin time and INR; monitor coagulation parameters.
Probenecid
May increase cefixime plasma levels and prolong its half-life by decreasing renal tubular secretion.
Carbamazepine
Cefixime may increase carbamazepine levels; monitor for toxicity.
Oral Anticoagulants
Enhanced anticoagulant effect, requiring careful monitoring.
Storage
Store the dry powder below 30°C. Protect from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard after 7 to 14 days.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Animal reproduction studies have shown no risk, but human data are limited. Should be used during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or to other cephalosporin antibiotics.
- History of severe hypersensitivity reaction to any penicillin.
Drug Interactions
Warfarin
May increase prothrombin time and INR; monitor coagulation parameters.
Probenecid
May increase cefixime plasma levels and prolong its half-life by decreasing renal tubular secretion.
Carbamazepine
Cefixime may increase carbamazepine levels; monitor for toxicity.
Oral Anticoagulants
Enhanced anticoagulant effect, requiring careful monitoring.
Storage
Store the dry powder below 30°C. Protect from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard after 7 to 14 days.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Animal reproduction studies have shown no risk, but human data are limited. Should be used during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months for dry powder. 7 to 14 days after reconstitution when stored in refrigerator.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by relevant authorities (e.g., FDA, DGDA)
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of Cefixime in various bacterial infections across different age groups, including its use in pediatric populations for otitis media and respiratory infections.
Lab Monitoring
- Regular monitoring of renal function in patients with pre-existing renal impairment.
- Periodic assessment of hematologic parameters (e.g., CBC) for patients on prolonged therapy.
Doctor Notes
- Prescribe Cefixime only for bacterial infections; it is not effective against viral infections.
- Counsel patients on the importance of completing the full course to prevent antibiotic resistance.
- Be aware of potential drug interactions, especially with anticoagulants.
Patient Guidelines
- Complete the full course of antibiotic treatment, even if symptoms improve.
- Do not share this medication with others, and do not save it for future infections.
- Contact your doctor if you experience severe diarrhea, rash, or any unusual symptoms.
- Shake the suspension well before each use and measure the dose accurately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cefixime may cause dizziness in some patients. Patients should be cautioned about operating machinery or driving if they experience such effects.
Lifestyle Advice
- Maintain adequate hydration.
- Ensure sufficient rest to aid recovery.
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