Viera
Generic Name
Sildenafil Citrate
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| viera 50 mg tablet | ৳ 50.00 | ৳ 500.00 |
Description
Overview of the medicine
Viera 50 mg Tablet contains Sildenafil Citrate, a phosphodiesterase-5 (PDE5) inhibitor, used to treat erectile dysfunction by increasing blood flow to the penis during sexual stimulation.
Uses & Indications
Dosage
Adults
The recommended dose is 50 mg taken approximately 1 hour before sexual activity. Based on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg. Maximum recommended dosing frequency is once per day.
Elderly
No dosage adjustment is generally required for elderly patients (≥65 years).
Renal_impairment
For patients with severe renal impairment (creatinine clearance <30 mL/min), a starting dose of 25 mg should be considered.
How to Take
Take the tablet orally with water, approximately 1 hour before sexual activity. Can be taken with or without food, but food (especially high-fat meals) may delay the onset of action.
Mechanism of Action
Sildenafil selectively inhibits phosphodiesterase type 5 (PDE5), an enzyme responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. By inhibiting PDE5, Sildenafil increases cGMP levels, leading to smooth muscle relaxation and enhanced blood flow into the penis, resulting in an erection upon sexual stimulation.
Pharmacokinetics
Onset
Typically 30-60 minutes after oral administration.
Excretion
Excreted predominantly as metabolites in the feces (approximately 80% of administered oral dose) and to a lesser extent in the urine (approximately 13% of administered oral dose).
Half life
Approximately 3-5 hours.
Absorption
Rapidly absorbed. Mean absolute bioavailability of about 41%. Peak plasma concentrations are reached within 30-120 minutes (median 60 minutes) of oral dosing in the fasted state.
Metabolism
Primarily metabolized by CYP3A4 (major route) and CYP2C9 (minor route) in the liver. The major circulating metabolite, N-desmethyl sildenafil, has similar PDE5 selectivity to sildenafil and accounts for approximately 20% of the pharmacological activity.
Side Effects
Contraindications
- Concomitant use with nitrates (e.g., nitroglycerin), due to the risk of severe hypotension.
- Concomitant use with guanylate cyclase stimulators (e.g., riociguat).
- Patients with known hypersensitivity to sildenafil or any component of the tablet.
- Patients who have suffered a recent myocardial infarction, stroke, or life-threatening arrhythmia.
- Patients with severe hepatic impairment.
- Patients with hereditary degenerative retinal disorders, such as retinitis pigmentosa.
- Patients with hypotension (<90/50 mmHg).
Drug Interactions
Alcohol
Excessive alcohol intake may increase the risk of orthostatic hypotension.
Nitrates
Contraindicated due to potentiation of hypotensive effects.
Riociguat
Contraindicated due to risk of severe hypotension.
Alpha-blockers (e.g., prazosin)
Increased risk of symptomatic hypotension; initiate sildenafil at 25 mg.
CYP3A4 Inhibitors (e.g., ritonavir, ketoconazole, erythromycin)
Increased plasma levels of sildenafil; reduce sildenafil dose.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In studies with healthy volunteers of single doses up to 800 mg, adverse events were similar to those seen at lower doses but incidence rates were increased. In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly protein bound and not eliminated in the urine.
Pregnancy & Lactation
Viera is not indicated for use in women.
Side Effects
Contraindications
- Concomitant use with nitrates (e.g., nitroglycerin), due to the risk of severe hypotension.
- Concomitant use with guanylate cyclase stimulators (e.g., riociguat).
- Patients with known hypersensitivity to sildenafil or any component of the tablet.
- Patients who have suffered a recent myocardial infarction, stroke, or life-threatening arrhythmia.
- Patients with severe hepatic impairment.
- Patients with hereditary degenerative retinal disorders, such as retinitis pigmentosa.
- Patients with hypotension (<90/50 mmHg).
Drug Interactions
Alcohol
Excessive alcohol intake may increase the risk of orthostatic hypotension.
Nitrates
Contraindicated due to potentiation of hypotensive effects.
Riociguat
Contraindicated due to risk of severe hypotension.
Alpha-blockers (e.g., prazosin)
Increased risk of symptomatic hypotension; initiate sildenafil at 25 mg.
CYP3A4 Inhibitors (e.g., ritonavir, ketoconazole, erythromycin)
Increased plasma levels of sildenafil; reduce sildenafil dose.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In studies with healthy volunteers of single doses up to 800 mg, adverse events were similar to those seen at lower doses but incidence rates were increased. In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly protein bound and not eliminated in the urine.
Pregnancy & Lactation
Viera is not indicated for use in women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved (local regulatory authority)
Patent Status
Generic available
Clinical Trials
Sildenafil has undergone extensive clinical trials demonstrating its efficacy and safety for the treatment of erectile dysfunction. Key trials include placebo-controlled, randomized studies on various populations.
Lab Monitoring
- No specific routine lab monitoring is required for sildenafil use. Monitor blood pressure, especially in patients concomitantly taking alpha-blockers.
Doctor Notes
- Counsel patients on proper administration and potential side effects, particularly priapism and sudden vision/hearing loss.
- Assess cardiovascular status prior to prescribing, especially in older patients or those with risk factors.
- Emphasize strict contraindication with nitrates.
Patient Guidelines
- Take Viera 50 mg approximately 1 hour before sexual activity.
- Do not take more than one tablet within a 24-hour period.
- Avoid consuming large amounts of alcohol as it may increase the risk of side effects.
- Seek immediate medical attention if you experience an erection lasting more than 4 hours.
- Consult your doctor if you experience sudden vision or hearing loss.
- Inform your doctor about all other medications you are taking, especially nitrates.
Missed Dose Advice
Viera is taken on an as-needed basis, so there is no regular dosing schedule. If you plan for sexual activity, take the tablet as advised. Do not take more than one dose per day.
Driving Precautions
Viera may cause dizziness or visual disturbances (e.g., blurred vision). Patients should be aware of how they react to Viera before driving or operating machinery.
Lifestyle Advice
- Maintain a healthy lifestyle, including regular exercise and a balanced diet, to improve overall cardiovascular health which can contribute to erectile function.
- Reduce stress and anxiety, as these can affect sexual performance.
- Quit smoking, as smoking is a risk factor for erectile dysfunction.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Viera Brand
Other medicines available under the same brand name
