Vilet-B
Generic Name
Pyridoxine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vilet b 5 mg tablet | ৳ 0.44 | N/A |
Description
Overview of the medicine
Vilet-B 5 mg Tablet contains Pyridoxine Hydrochloride, commonly known as Vitamin B6. It is an essential water-soluble vitamin involved in numerous metabolic processes, including amino acid metabolism, neurotransmitter synthesis, and red blood cell formation. It is primarily used to prevent or treat pyridoxine deficiency and associated conditions.
Uses & Indications
Dosage
Adults
For pyridoxine deficiency: 10-50 mg daily, or as directed by physician. Vilet-B 5 mg tablet: 2-10 tablets daily.
Elderly
Similar to adult dosage; no specific adjustment usually needed, or as directed by physician.
Renal_impairment
No specific dosage adjustment is typically required for mild to moderate renal impairment. Consult physician for severe cases.
How to Take
Vilet-B 5 mg Tablet should be taken orally, with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Pyridoxine functions as a coenzyme in over 100 enzymatic reactions, mainly in amino acid, carbohydrate, and fat metabolism. Its active forms, pyridoxal phosphate (PLP) and pyridoxamine phosphate (PMP), are crucial for neurotransmitter synthesis (serotonin, norepinephrine, GABA) and heme synthesis.
Pharmacokinetics
Onset
Therapeutic effects for deficiency correction can be observed within hours to days.
Excretion
Excreted primarily in the urine, mainly as 4-pyridoxic acid, the major inactive metabolite.
Half life
The plasma half-life of unbound pyridoxine is relatively short (2-3 hours), but the active coenzyme forms (PLP) have a longer half-life of 15-20 days due to tissue binding.
Absorption
Readily absorbed from the gastrointestinal tract, primarily in the jejunum. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Metabolized in the liver to its active forms, pyridoxal phosphate (PLP) and pyridoxamine phosphate (PMP).
Side Effects
Contraindications
- Hypersensitivity to pyridoxine or any component of the formulation.
Drug Interactions
Levodopa
Pyridoxine can reduce the efficacy of levodopa (only when levodopa is not co-administered with a decarboxylase inhibitor like carbidopa).
Isoniazid
Isoniazid can increase pyridoxine requirements and lead to deficiency. Pyridoxine supplementation is often given concurrently.
Penicillamine, Cycloserine, Hydralazine, Oral Contraceptives
These drugs can also increase pyridoxine requirements and potentially lead to deficiency.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
While pyridoxine is water-soluble and generally safe, very high doses (e.g., >200 mg/day) taken long-term can lead to sensory neuropathy, characterized by numbness and tingling in the extremities. Treatment involves discontinuing the supplement.
Pregnancy & Lactation
Pyridoxine is generally considered safe during pregnancy and lactation when taken at recommended doses. It is sometimes used to manage nausea and vomiting during pregnancy. Consult your doctor for appropriate dosage.
Side Effects
Contraindications
- Hypersensitivity to pyridoxine or any component of the formulation.
Drug Interactions
Levodopa
Pyridoxine can reduce the efficacy of levodopa (only when levodopa is not co-administered with a decarboxylase inhibitor like carbidopa).
Isoniazid
Isoniazid can increase pyridoxine requirements and lead to deficiency. Pyridoxine supplementation is often given concurrently.
Penicillamine, Cycloserine, Hydralazine, Oral Contraceptives
These drugs can also increase pyridoxine requirements and potentially lead to deficiency.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
While pyridoxine is water-soluble and generally safe, very high doses (e.g., >200 mg/day) taken long-term can lead to sensory neuropathy, characterized by numbness and tingling in the extremities. Treatment involves discontinuing the supplement.
Pregnancy & Lactation
Pyridoxine is generally considered safe during pregnancy and lactation when taken at recommended doses. It is sometimes used to manage nausea and vomiting during pregnancy. Consult your doctor for appropriate dosage.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture, depending on manufacturer specifications.
Availability
Pharmacies, drugstores
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Pyridoxine is a well-established vitamin, and its efficacy and safety profile have been extensively studied and documented over decades. Modern clinical trials typically focus on new formulations or specific therapeutic applications.
Lab Monitoring
- Routine lab monitoring is not typically required for pyridoxine 5 mg tablet.
- In cases of suspected severe deficiency or toxicity, plasma pyridoxal phosphate (PLP) levels may be monitored.
Doctor Notes
- Counsel patients on the importance of a balanced diet alongside supplementation.
- Inquire about other medications, especially isoniazid, levodopa, and oral contraceptives, which may interact with pyridoxine.
- Advise patients to report any symptoms of neuropathy (e.g., numbness, tingling) especially if taking higher doses.
Patient Guidelines
- Take Vilet-B 5 mg Tablet exactly as prescribed by your doctor or as indicated on the package.
- Do not exceed the recommended dose without consulting a healthcare professional.
- Inform your doctor or pharmacist about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Vilet-B 5 mg Tablet is not known to impair the ability to drive or operate machinery. However, if you experience any unusual side effects, avoid such activities.
Lifestyle Advice
- Maintain a balanced diet rich in essential vitamins and minerals.
- Consult a nutritionist for dietary advice if you have specific deficiencies.
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