Vinca
Generic Name
Vinorelbine 10 mg Tablet
Manufacturer
Example Pharma Co.
Country
Various
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vinca 10 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Vinca-10-mg-tablet is an oral antineoplastic agent containing Vinorelbine, a vinca alkaloid. It is used in the treatment of various cancers by interfering with cell division.
Uses & Indications
Dosage
Adults
Typically 60 mg/m² orally once weekly for 3 weeks followed by one week rest, adjusted based on tolerability and blood counts. Max 80 mg/m² for subsequent cycles.
Elderly
No specific dose adjustment based solely on age, but close monitoring of toxicity.
Renal_impairment
No specific dose adjustment required for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Administer orally, with or without food. Swallow whole, do not chew, crush, or open the tablet.
Mechanism of Action
Vinorelbine binds to tubulin, inhibiting its polymerization into microtubules. This disrupts the formation of the mitotic spindle, leading to metaphase arrest and subsequent apoptosis of cancer cells.
Pharmacokinetics
Onset
Not immediate; therapeutic effects are observed over cycles of treatment.
Excretion
Mainly excreted via the bile and feces, with a small portion via urine.
Half life
Terminal half-life is approximately 27-40 hours.
Absorption
Rapidly absorbed after oral administration; bioavailability is approximately 40%.
Metabolism
Primarily metabolized in the liver by CYP3A4 to active and inactive metabolites.
Side Effects
Contraindications
- Severe neutropenia (<1500 cells/mm³)
- Severe thrombocytopenia
- Pregnancy and breastfeeding
- Severe hepatic impairment
Drug Interactions
Live vaccines
Avoid due to immunosuppression.
CYP3A4 inducers (e.g., phenytoin, rifampicin)
May decrease Vinorelbine levels and efficacy.
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May increase Vinorelbine levels and toxicity.
Storage
Store below 25°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe myelosuppression, peripheral neurotoxicity, and gastrointestinal toxicity. Management is supportive care, including blood product transfusions and G-CSF for neutropenia.
Pregnancy & Lactation
Pregnancy Category D: Known to cause fetal harm. Avoid during pregnancy. Breastfeeding is contraindicated due to potential harm to the infant.
Side Effects
Contraindications
- Severe neutropenia (<1500 cells/mm³)
- Severe thrombocytopenia
- Pregnancy and breastfeeding
- Severe hepatic impairment
Drug Interactions
Live vaccines
Avoid due to immunosuppression.
CYP3A4 inducers (e.g., phenytoin, rifampicin)
May decrease Vinorelbine levels and efficacy.
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May increase Vinorelbine levels and toxicity.
Storage
Store below 25°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe myelosuppression, peripheral neurotoxicity, and gastrointestinal toxicity. Management is supportive care, including blood product transfusions and G-CSF for neutropenia.
Pregnancy & Lactation
Pregnancy Category D: Known to cause fetal harm. Avoid during pregnancy. Breastfeeding is contraindicated due to potential harm to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in specialized pharmacies and hospital dispensaries
Approval Status
Approved by FDA and other regulatory bodies for oncology indications.
Patent Status
Off-patent (for generic Vinorelbine)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy in NSCLC and MBC, with ongoing research into other indications and combinations.
Lab Monitoring
- Complete Blood Count (CBC) with differential before each cycle
- Liver function tests
- Renal function tests
Doctor Notes
- Careful monitoring of blood counts (especially neutrophils) is crucial before each dose.
- Assess for signs of peripheral neuropathy regularly.
- Ensure adequate antiemetic prophylaxis for nausea/vomiting.
Patient Guidelines
- Report any fever, bleeding, or unusual bruising immediately.
- Avoid contact with people who are sick or have infections.
- Use effective contraception during and for a period after treatment.
- Do not drive or operate heavy machinery if experiencing dizziness or fatigue.
Missed Dose Advice
If a dose is missed, contact your doctor immediately. Do not take a double dose to compensate.
Driving Precautions
May cause dizziness, fatigue, or visual disturbances. Advise patients not to drive or operate machinery if affected.
Lifestyle Advice
- Maintain good hygiene to reduce infection risk.
- Eat a balanced diet and stay hydrated.
- Avoid alcohol and smoking.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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