Vini
Generic Name
Vinpocetine 10 mg Tablet
Manufacturer
Local/International Pharmaceutical Company
Country
Varies by manufacturer
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vini 10 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Vinpocetine is a synthetic derivative of the Vinca minor alkaloid vincamine. It is primarily used to improve cerebral blood flow and enhance cognitive function. It acts as a phosphodiesterase type 1 (PDE1) inhibitor, leading to vasodilation and increased blood flow in the brain.
Uses & Indications
Dosage
Adults
Usually 5-10 mg three times daily, adjusted according to patient response. Max 30 mg/day.
Elderly
No specific dose adjustment required, but start with lower doses and monitor.
Renal_impairment
No specific dose adjustment needed.
How to Take
Take orally, preferably after meals to enhance absorption and reduce gastrointestinal upset.
Mechanism of Action
Vinpocetine selectively inhibits phosphodiesterase type 1 (PDE1) in the brain, leading to increased levels of cyclic GMP (cGMP). This results in vasodilation, improved cerebral blood flow, and enhanced oxygen and glucose utilization by brain cells. It also has neuroprotective and anti-inflammatory properties.
Pharmacokinetics
Onset
Effects can be observed within 30-60 minutes.
Excretion
Primarily excreted in urine and feces as metabolites.
Half life
Approximately 2-3 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract. Bioavailability is around 7% due to significant first-pass metabolism.
Metabolism
Extensively metabolized in the liver (primarily by hydrolysis to apovincaminic acid and then further conjugation).
Side Effects
Contraindications
- Hypersensitivity to vinpocetine or any component
- Acute cerebral hemorrhage
- Severe ischemic heart disease
- Severe arrhythmias
- Pregnancy and lactation
Drug Interactions
Anticoagulants
May increase risk of bleeding.
Antihypertensives
May enhance hypotensive effect.
Antiplatelet agents
May increase risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include increased side effects. Management is symptomatic and supportive. Gastric lavage may be considered if recent ingestion.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation due to lack of sufficient safety data and potential risks.
Side Effects
Contraindications
- Hypersensitivity to vinpocetine or any component
- Acute cerebral hemorrhage
- Severe ischemic heart disease
- Severe arrhythmias
- Pregnancy and lactation
Drug Interactions
Anticoagulants
May increase risk of bleeding.
Antihypertensives
May enhance hypotensive effect.
Antiplatelet agents
May increase risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include increased side effects. Management is symptomatic and supportive. Gastric lavage may be considered if recent ingestion.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation due to lack of sufficient safety data and potential risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved by various international regulatory bodies; regulatory status as a dietary supplement in some regions.
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have investigated vinpocetine's efficacy in improving cognitive function and cerebral blood flow, particularly in elderly patients with cerebrovascular insufficiency. Some studies show positive results, while others call for more rigorous, large-scale trials.
Lab Monitoring
- Blood pressure (especially in hypotensive patients)
- ECG (in patients with cardiac conditions)
- Coagulation parameters (if co-administered with anticoagulants)
Doctor Notes
- Advise patients to report any unusual bleeding or bruising.
- Consider potential interactions with other cardiovascular medications.
- Emphasize taking the medication with food for better absorption.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Inform your doctor about all other medications you are taking, including herbal supplements.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or lightheadedness, especially at the start of treatment. Patients should be cautious when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain a healthy lifestyle with regular exercise and a balanced diet.
- Avoid smoking and excessive alcohol consumption.
- Manage underlying conditions like hypertension or diabetes effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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