Vini
Generic Name
Vinpocetine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vini 20 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Vini 20 mg Tablet contains Vinpocetine, a synthetic derivative of the Vinca alkaloid vincamine. It is primarily used to improve cerebral blood flow, oxygen utilization, and neuronal metabolism, thereby enhancing cognitive functions.
Uses & Indications
Dosage
Adults
Initial treatment: 10-20 mg three times daily, usually 20 mg three times daily. Maintenance dose: 10 mg three times daily. Should be taken with or after meals.
Elderly
No specific dose adjustment is usually required for elderly patients, but caution is advised in those with severe underlying conditions.
Renal_impairment
No dose adjustment needed for mild to moderate renal impairment. Use with caution in severe impairment as data is limited.
How to Take
Oral administration. Tablets should be swallowed whole with a sufficient amount of liquid, preferably with or after meals to enhance absorption and minimize gastrointestinal discomfort.
Mechanism of Action
Vinpocetine inhibits phosphodiesterase type 1 (PDE1), leading to increased cyclic guanosine monophosphate (cGMP) levels within cerebral smooth muscle cells. This results in vasodilation, improved cerebral microcirculation, and enhanced oxygen and glucose uptake by brain tissues. It also has neuroprotective, anti-inflammatory, and antioxidant properties.
Pharmacokinetics
Onset
Clinical effects may be observed within hours, but optimal therapeutic benefits usually require several weeks of continuous treatment.
Excretion
Mainly excreted renally (60%) and fecally (40%), primarily as metabolites. Less than 5% is excreted unchanged.
Half life
Plasma elimination half-life is approximately 1-2 hours. Metabolites have longer half-lives.
Absorption
Rapidly absorbed after oral administration; however, absolute bioavailability is low (approx. 7%). Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily via hydrolysis to apovincaminic acid (AVA) and subsequent demethylation. Several active and inactive metabolites are formed.
Side Effects
Contraindications
- Known hypersensitivity to Vinpocetine or any component of the formulation
- Pregnancy and lactation
- Acute cerebrovascular hemorrhage
- Severe cardiac arrhythmia, especially prolonged QT syndrome
- Children and adolescents due to lack of safety data
Drug Interactions
Antihypertensives
Vinpocetine may cause a slight reduction in blood pressure, potentially enhancing the effects of antihypertensive medications. Monitor blood pressure.
Anticoagulants (e.g., Warfarin, Heparin)
Vinpocetine may potentiate the effect of anticoagulants, increasing the risk of bleeding. Close monitoring of INR and prothrombin time is recommended.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Concomitant use may increase the risk of bleeding due to vinpocetine's mild antiplatelet effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include increased blood pressure, headache, flushing, and possibly exacerbation of known side effects. Treatment should be symptomatic and supportive. Gastric lavage and activated charcoal may be considered in acute ingestion.
Pregnancy & Lactation
Vinpocetine is contraindicated during pregnancy due to potential for uterine contractions and during lactation as it is excreted in breast milk and its effects on the infant are unknown.
Side Effects
Contraindications
- Known hypersensitivity to Vinpocetine or any component of the formulation
- Pregnancy and lactation
- Acute cerebrovascular hemorrhage
- Severe cardiac arrhythmia, especially prolonged QT syndrome
- Children and adolescents due to lack of safety data
Drug Interactions
Antihypertensives
Vinpocetine may cause a slight reduction in blood pressure, potentially enhancing the effects of antihypertensive medications. Monitor blood pressure.
Anticoagulants (e.g., Warfarin, Heparin)
Vinpocetine may potentiate the effect of anticoagulants, increasing the risk of bleeding. Close monitoring of INR and prothrombin time is recommended.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Concomitant use may increase the risk of bleeding due to vinpocetine's mild antiplatelet effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include increased blood pressure, headache, flushing, and possibly exacerbation of known side effects. Treatment should be symptomatic and supportive. Gastric lavage and activated charcoal may be considered in acute ingestion.
Pregnancy & Lactation
Vinpocetine is contraindicated during pregnancy due to potential for uterine contractions and during lactation as it is excreted in breast milk and its effects on the infant are unknown.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have investigated Vinpocetine's efficacy in improving cognitive function and treating cerebrovascular disorders, showing mixed but generally positive results, especially in chronic conditions.
Lab Monitoring
- Blood pressure monitoring (especially in patients with cardiovascular conditions)
- INR monitoring (for patients on anticoagulants)
- Periodic liver function tests in long-term use
Doctor Notes
- Emphasize the importance of taking Vini with food to optimize absorption and efficacy.
- Advise caution and close monitoring for patients concurrently taking anticoagulants or antiplatelet agents due to increased bleeding risk.
- Contraindicated in pregnancy and lactation; ensure patients are aware of this.
- Remind patients that therapeutic effects may take several weeks to become noticeable.
Patient Guidelines
- Take the tablet with or after food as directed by your doctor.
- Do not crush or chew the tablet; swallow it whole.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a forgotten one.
Driving Precautions
Vinpocetine may cause dizziness, lightheadedness, or sleepiness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain a healthy and balanced diet rich in antioxidants.
- Engage in regular physical activity to promote cardiovascular health.
- Avoid smoking and limit alcohol consumption.
- Regular mental exercises (e.g., puzzles, reading) may support cognitive function.
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