Vintelix
Generic Name
Vintelix 10 mg Tablet
Manufacturer
PharmaCorp Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vintelix 10 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Vintelix 10 mg Tablet is an antidepressant primarily used to treat major depressive disorder and generalized anxiety disorder. It helps restore the balance of certain natural substances (neurotransmitters) in the brain, improving mood and feelings of well-being.
Uses & Indications
Dosage
Adults
Initial dose 10 mg once daily, may be increased to 20 mg after 1-2 weeks based on response. Maximum recommended dose is 20 mg/day.
Elderly
Initial dose 5 mg once daily, may be increased to 10 mg. Maximum 10 mg/day.
Renal_impairment
No dose adjustment needed for mild to moderate impairment. Use with caution in severe impairment; consider 5 mg daily.
How to Take
Take orally once daily, with or without food, preferably at the same time each day. Swallow the tablet whole with water, do not chew or crush.
Mechanism of Action
Vintelix works by selectively inhibiting the reuptake of serotonin in the brain, leading to increased serotonin concentrations in the synaptic cleft. This enhanced serotonergic activity is believed to modulate mood and anxiety symptoms.
Pharmacokinetics
Onset
Initial therapeutic effects observed within 1-2 weeks, full effects in 4-6 weeks.
Excretion
Mainly excreted via urine as metabolites, with a small portion in feces.
Half life
Approximately 20-25 hours.
Absorption
Well absorbed orally, peak plasma concentrations reached within 4-6 hours.
Metabolism
Extensively metabolized in the liver, primarily via CYP2D6 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Vintelix or any excipients
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI
- Severe hepatic impairment
Drug Interactions
MAOIs
Risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability, mental status changes).
Alcohol
Enhances CNS depressant effects; avoid concomitant use.
Triptans
Increased risk of serotonin syndrome.
Warfarin
Increased risk of bleeding due to effects on platelet function.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, tachycardia, tremor, seizures, and serotonin syndrome. Management is primarily supportive; maintain airway, monitor cardiac rhythm and vital signs. Activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Category C for pregnancy. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding due to potential excretion into breast milk and adverse effects on the infant.
Side Effects
Contraindications
- Hypersensitivity to Vintelix or any excipients
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI
- Severe hepatic impairment
Drug Interactions
MAOIs
Risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability, mental status changes).
Alcohol
Enhances CNS depressant effects; avoid concomitant use.
Triptans
Increased risk of serotonin syndrome.
Warfarin
Increased risk of bleeding due to effects on platelet function.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, tachycardia, tremor, seizures, and serotonin syndrome. Management is primarily supportive; maintain airway, monitor cardiac rhythm and vital signs. Activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Category C for pregnancy. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding due to potential excretion into breast milk and adverse effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent pending
Clinical Trials
Extensive phase III clinical trials demonstrated Vintelix's efficacy in major depressive disorder and generalized anxiety disorder, showing significant improvements in HAM-D and GAD-7 scores compared to placebo.
Lab Monitoring
- Baseline liver and renal function tests
- Electrolytes (especially sodium) if hyponatremia is a concern
- Periodic monitoring for suicidal ideation
Doctor Notes
- Counsel patients on delayed onset of action and the importance of continued therapy.
- Monitor for emergent suicidality, especially at treatment initiation or dose changes.
- Consider drug interactions with other serotonergic agents.
Patient Guidelines
- Do not stop taking Vintelix abruptly; sudden discontinuation can lead to withdrawal symptoms.
- It may take several weeks to feel the full effects of the medication.
- Report any unusual mood changes or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Vintelix may cause dizziness, drowsiness, or blurred vision. Avoid driving or operating heavy machinery until you know how this medication affects you.
Lifestyle Advice
- Avoid alcohol consumption while on this medication.
- Engage in regular physical activity and maintain a balanced diet.
- Practice stress-reduction techniques like meditation or yoga.
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Global Brand Names
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