Vintelix
Generic Name
Vintelix 5 mg Tablet
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vintelix 5 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Vintelix 5 mg Tablet is an antidepressant belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class of medicines. It is primarily used to treat major depressive disorder and various anxiety disorders by helping to restore the balance of a certain natural substance (serotonin) in the brain. This medication helps improve mood, sleep, appetite, and energy level.
Uses & Indications
Dosage
Adults
Initial dose: 5 mg orally once daily. May be increased to 10 mg after 1 week if needed, up to a maximum of 20 mg/day, based on clinical response and tolerability.
Elderly
A lower initial dose, such as 2.5 mg or 5 mg once daily, is recommended. Dosage adjustments should be made cautiously due to potentially reduced metabolism.
Renal_impairment
No dosage adjustment is generally required for mild to moderate renal impairment. For severe renal impairment, caution is advised and a lower starting dose may be considered.
How to Take
Take Vintelix 5 mg Tablet orally once daily, with or without food. It is recommended to take it at the same time each day to maintain consistent drug levels. Do not crush, chew, or break the tablet; swallow it whole.
Mechanism of Action
Vintelix acts by selectively inhibiting the reuptake of serotonin (5-HT) by presynaptic neurons in the central nervous system. This leads to an increased concentration of serotonin in the synaptic cleft, thereby enhancing serotonergic neurotransmission. This mechanism is believed to be responsible for its antidepressant and anxiolytic effects.
Pharmacokinetics
Onset
Initial therapeutic effects may be seen within 1-2 weeks, with full effects typically appearing after 4-6 weeks of consistent use.
Excretion
Mainly excreted through the urine as metabolites, with a small portion excreted in feces.
Half life
Approximately 20-30 hours, allowing for once-daily dosing.
Absorption
Rapidly and well absorbed from the gastrointestinal tract, with peak plasma concentrations reached within 4-6 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 (CYP) enzymes, particularly CYP2D6 and CYP3A4, into inactive or less active metabolites.
Side Effects
Contraindications
- Hypersensitivity to Vintelix or any of its excipients.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment.
- Concomitant use with pimozide.
Drug Interactions
MAOIs
Concurrent use is contraindicated due to the risk of serotonin syndrome, which can be fatal.
NSAIDs
Increased risk of gastrointestinal bleeding when co-administered.
Triptans
Increased risk of serotonin syndrome; use with caution.
Warfarin
Increased risk of bleeding due to Vintelix's effect on platelet aggregation; INR monitoring is recommended.
Tricyclic Antidepressants (TCAs)
May increase plasma concentrations of TCAs, requiring dose adjustment.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of Vintelix overdose may include nausea, vomiting, drowsiness, dizziness, tremor, agitation, tachycardia, and rarely, seizures or serotonin syndrome. Management involves general supportive measures, maintaining an open airway, monitoring cardiac and vital signs, and symptomatic treatment. Gastric lavage and activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category C. Vintelix should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Vintelix is excreted in human milk; caution should be exercised when Vintelix is administered to a nursing mother. Consult a doctor before use during pregnancy or lactation.
Side Effects
Contraindications
- Hypersensitivity to Vintelix or any of its excipients.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment.
- Concomitant use with pimozide.
Drug Interactions
MAOIs
Concurrent use is contraindicated due to the risk of serotonin syndrome, which can be fatal.
NSAIDs
Increased risk of gastrointestinal bleeding when co-administered.
Triptans
Increased risk of serotonin syndrome; use with caution.
Warfarin
Increased risk of bleeding due to Vintelix's effect on platelet aggregation; INR monitoring is recommended.
Tricyclic Antidepressants (TCAs)
May increase plasma concentrations of TCAs, requiring dose adjustment.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of Vintelix overdose may include nausea, vomiting, drowsiness, dizziness, tremor, agitation, tachycardia, and rarely, seizures or serotonin syndrome. Management involves general supportive measures, maintaining an open airway, monitoring cardiac and vital signs, and symptomatic treatment. Gastric lavage and activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category C. Vintelix should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Vintelix is excreted in human milk; caution should be exercised when Vintelix is administered to a nursing mother. Consult a doctor before use during pregnancy or lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent pending
Clinical Trials
Vintelix underwent rigorous placebo-controlled and active-controlled clinical trials demonstrating its efficacy and safety in the treatment of major depressive disorder and anxiety disorders across diverse patient populations. Phase 3 trials supported its current indications and dosage recommendations.
Lab Monitoring
- Monitor for changes in mood and behavior, especially suicidality, during initiation and dose adjustments.
- Regular monitoring of liver function tests may be considered in patients with hepatic impairment.
- Monitor serum sodium levels, especially in elderly patients or those on diuretics, due to the risk of hyponatremia.
Doctor Notes
- Advise patients regarding the delayed onset of therapeutic effects and the importance of consistent adherence to treatment.
- Educate patients and their caregivers about the black box warning concerning suicidality, especially in younger populations.
- Implement a gradual tapering schedule when discontinuing Vintelix to minimize withdrawal symptoms.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Vintelix suddenly without consulting your doctor, as this may lead to withdrawal symptoms.
- Be aware that it may take several weeks for the full antidepressant effects to be observed.
- Report any new or worsening symptoms of depression, suicidal thoughts, or unusual changes in behavior to your doctor immediately.
Missed Dose Advice
If you miss a dose of Vintelix, take it as soon as you remember. If it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Vintelix may cause dizziness, drowsiness, or blurred vision. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that Vintelix therapy does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Avoid alcohol consumption while taking Vintelix, as it can worsen side effects.
- Engage in regular physical activity and maintain a balanced diet to support overall mental and physical well-being.
- Practice stress-reduction techniques such as mindfulness or meditation.
- Ensure adequate sleep for better mental health management.
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