Virzith
Generic Name
Azithromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| virzith 200 mg suspension | ৳ 100.00 | N/A |
Description
Overview of the medicine
Virzith 200 mg Suspension is a macrolide antibiotic used to treat various bacterial infections, including respiratory tract infections, skin infections, and sexually transmitted diseases. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Typically 500 mg once daily for 3 days, or 500 mg on day 1 followed by 250 mg once daily for 4 days.
Elderly
No dosage adjustment is generally required for elderly patients with normal renal and hepatic function.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Caution with severe impairment.
How to Take
Administer orally, preferably on an empty stomach (1 hour before or 2 hours after food). Shake the suspension well before each use.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby interfering with translocation of peptides.
Pharmacokinetics
Onset
Within 2-3 hours
Excretion
Mainly via bile as unchanged drug, a small amount renally.
Half life
68 hours (terminal half-life)
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.
Metabolism
Primarily hepatic, but minimal metabolism occurs.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased azithromycin concentration.
Antacids (containing aluminum or magnesium)
Reduced peak serum concentration of azithromycin, take azithromycin at least 1 hour before or 2 hours after antacids.
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension at room temperature (20-25°C) or refrigerated (2-8°C), do not freeze.
Overdose
Symptoms include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment involves symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased azithromycin concentration.
Antacids (containing aluminum or magnesium)
Reduced peak serum concentration of azithromycin, take azithromycin at least 1 hour before or 2 hours after antacids.
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension at room temperature (20-25°C) or refrigerated (2-8°C), do not freeze.
Overdose
Symptoms include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment involves symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: 2 years. Reconstituted suspension: 5-10 days (stored at room temperature or refrigerated, depending on manufacturer)
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established azithromycin's efficacy and safety for various bacterial infections since its approval.
Lab Monitoring
- Liver function tests (in patients with pre-existing hepatic impairment)
- INR (for patients on warfarin)
- ECG (in patients at risk of QT prolongation)
Doctor Notes
- Advise patients to complete the full course to prevent antibiotic resistance.
- Counsel on proper reconstitution and administration technique for suspensions.
- Monitor for signs of C. difficile-associated diarrhea.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Do not save medication for future use.
- Report any severe or persistent side effects to your doctor.
- Shake suspension well before each dose.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness; caution is advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea or vomiting.
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Global Brand Names
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