Virzith
Generic Name
Virzithromycin
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| virzith 500 mg tablet | ৳ 30.00 | N/A |
Description
Overview of the medicine
Virzith 500 mg Tablet is a broad-spectrum macrolide antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
For most infections: 500 mg once daily for 3 days, or 500 mg on day 1 followed by 250 mg daily on days 2-5.
Elderly
No dosage adjustment generally required unless severe renal or hepatic impairment.
Renal_impairment
Mild to moderate: No adjustment. Severe: Use with caution, consider dosage reduction.
How to Take
May be taken with or without food. To minimize gastrointestinal upset, it can be taken with food.
Mechanism of Action
Virzithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing translocation of peptides.
Pharmacokinetics
Onset
Clinical improvement usually seen within 2-3 days.
Excretion
Primarily excreted unchanged in the bile; a small amount excreted in urine.
Half life
Approximately 2-4 days (terminal half-life).
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is about 37%.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to virzithromycin or any macrolide antibiotic
- Severe hepatic impairment
Drug Interactions
Digoxin
May increase digoxin levels; monitor digoxin levels.
Warfarin
May increase the anticoagulant effect, requiring INR monitoring.
Antacids (containing aluminum or magnesium)
May decrease the peak plasma concentration of virzithromycin; separate administration by 2-3 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe gastrointestinal upset (nausea, vomiting, diarrhea) and hearing loss. Management involves supportive care and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to virzithromycin or any macrolide antibiotic
- Severe hepatic impairment
Drug Interactions
Digoxin
May increase digoxin levels; monitor digoxin levels.
Warfarin
May increase the anticoagulant effect, requiring INR monitoring.
Antacids (containing aluminum or magnesium)
May decrease the peak plasma concentration of virzithromycin; separate administration by 2-3 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe gastrointestinal upset (nausea, vomiting, diarrhea) and hearing loss. Management involves supportive care and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety in indicated bacterial infections. Post-marketing surveillance continues.
Lab Monitoring
- Liver function tests (LFTs) in patients with pre-existing hepatic impairment
- INR for patients on warfarin
- Digoxin levels if co-administered
Doctor Notes
- Advise patients to complete the full course of treatment.
- Monitor liver function in patients with pre-existing hepatic conditions.
- Caution with concomitant use of drugs known to prolong QT interval.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Do not share this medicine with others.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; use caution when driving or operating machinery.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Avoid alcohol consumption during treatment, as it may worsen side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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