Viscoryl
Generic Name
Ketotifen Fumarate
Manufacturer
Incepta Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| viscoryl 1 mg tablet | ৳ 0.90 | ৳ 9.00 |
Description
Overview of the medicine
Ketotifen is a mast cell stabilizer and H1-antihistamine used for the prophylactic treatment of asthma and symptomatic treatment of allergic conjunctivitis and rhinitis.
Uses & Indications
Dosage
Adults
1 mg twice daily. May be increased to 2 mg twice daily in severe cases.
Elderly
No specific dose adjustment needed, use with caution.
Renal_impairment
No specific data, use with caution.
How to Take
Oral, with food, twice daily.
Mechanism of Action
Ketotifen stabilizes mast cells, preventing the release of inflammatory mediators (like histamine and leukotrienes). It also possesses H1-antihistaminic activity.
Pharmacokinetics
Onset
For asthma prophylaxis, full therapeutic effect develops over several weeks. Antihistamine effect is faster.
Excretion
Primarily renal (60-70% as metabolites), fecal (20-30%).
Half life
Biphasic elimination, terminal half-life approx. 21 hours.
Absorption
Well absorbed orally, bioavailability approx. 50% due to first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily via glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to ketotifen or any component.
- Concomitant use with oral antidiabetics (risk of reversible platelet count decrease).
Drug Interactions
Oral Antidiabetics
Risk of reversible platelet count decrease.
Other Antihistamines
Additive anticholinergic effects.
CNS Depressants (e.g., Alcohol, Sedatives, Hypnotics)
Increased sedation and central nervous system depression.
Storage
Store below 30°C, protect from light and moisture.
Overdose
Symptoms: Drowsiness, confusion, disorientation, tachycardia, hypotension. Management: Symptomatic and supportive, gastric lavage, activated charcoal.
Pregnancy & Lactation
Pregnancy Category C. Avoid during lactation. Consult doctor.
Side Effects
Contraindications
- Hypersensitivity to ketotifen or any component.
- Concomitant use with oral antidiabetics (risk of reversible platelet count decrease).
Drug Interactions
Oral Antidiabetics
Risk of reversible platelet count decrease.
Other Antihistamines
Additive anticholinergic effects.
CNS Depressants (e.g., Alcohol, Sedatives, Hypnotics)
Increased sedation and central nervous system depression.
Storage
Store below 30°C, protect from light and moisture.
Overdose
Symptoms: Drowsiness, confusion, disorientation, tachycardia, hypotension. Management: Symptomatic and supportive, gastric lavage, activated charcoal.
Pregnancy & Lactation
Pregnancy Category C. Avoid during lactation. Consult doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to product packaging for specific date.
Availability
Pharmacies
Approval Status
Approved in many countries
Patent Status
Off-patent (Generic available)
Clinical Trials
Ketotifen is a well-established drug with extensive clinical trials demonstrating its efficacy and safety in asthma prophylaxis and allergic conditions.
Lab Monitoring
- Blood counts (if co-administered with oral antidiabetics)
- Liver function tests (occasionally)
Doctor Notes
- Prescribe with caution in patients with epilepsy due to potential for lowering seizure threshold.
- Counsel patients on the delayed onset of full therapeutic effect for asthma prophylaxis.
Patient Guidelines
- May cause drowsiness; avoid driving or operating machinery initially.
- Do not discontinue abruptly if used for asthma prophylaxis.
- Full therapeutic effect for asthma may take several weeks.
Missed Dose Advice
Take as soon as remembered, unless it's almost time for the next dose. Do not double dose.
Driving Precautions
May impair ability to drive or operate machinery, especially at the start of treatment.
Lifestyle Advice
- Avoid alcohol due to additive sedative effects.
- Maintain regular follow-up with doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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