Oral administration, usually once daily in the morning with or without food. Swallow whole, do not chew or crush.

Bisoprolol is a highly cardioselective beta-1 adrenergic blocking agent. It selectively blocks beta-1 adrenergic receptors in the heart, leading to decreased heart rate, myocardial contractility, and cardiac output, thus lowering blood pressure.

• •Acute heart failure or decompensated heart failure requiring intravenous inotropic therapy
• •Cardiogenic shock
• •Second or third degree AV block without a pacemaker
• •Sick sinus syndrome without a pacemaker
• •Sinoatrial block
• •Symptomatic bradycardia (< 50 bpm)
• •Severe asthma or severe chronic obstructive pulmonary disease
• •Severe peripheral arterial occlusive disease
• •Metabolic acidosis

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms include bradycardia, hypotension, bronchospasm, acute cardiac insufficiency. Management involves supportive therapy, IV atropine for bradycardia, IV glucagon, IV beta-stimulants for cardiac depression, and bronchodilators for bronchospasm.

Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Bisoprolol is excreted in breast milk; caution should be exercised when administered to a nursing woman.