Various (e.g., Thiamine, Benfotiamine)
Generic Name
Vitamin-B1 (Thiamine)
Manufacturer
Various (e.g., Square Pharmaceuticals, Renata Limited)
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vitamin b1 100 mg injection | ৳ 3.50 | N/A |
Description
Overview of the medicine
Vitamin B1, also known as Thiamine, is an essential nutrient required for glucose metabolism and normal nerve, heart, and muscle function. It plays a crucial role in converting carbohydrates into energy.
Uses & Indications
Dosage
Adults
Deficiency: 5-30 mg daily, orally, in divided doses; severe deficiency: 100 mg IV/IM daily for 7 days. Maintenance: 5-10 mg daily. Wernicke-Korsakoff: 100 mg IV three times daily.
Elderly
Similar to adult dosage, but caution with renal impairment.
Renal_impairment
No specific dose adjustment for mild to moderate impairment; consult physician for severe cases.
How to Take
Oral tablets/capsules can be taken with or without food. Injections are administered intravenously or intramuscularly by a healthcare professional.
Mechanism of Action
Thiamine pyrophosphate (TPP), the active form of Vitamin B1, acts as a coenzyme in several key enzymatic reactions, particularly in carbohydrate metabolism (e.g., pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, transketolase).
Pharmacokinetics
Onset
Oral: hours to days; IV: minutes to hours for symptom improvement.
Excretion
Mainly through the urine as thiamine and its metabolites. Excess is excreted unchanged.
Half life
Approximately 98 minutes (active form).
Absorption
Readily absorbed from the small intestine, especially the duodenum, by active transport at low concentrations and passive diffusion at high concentrations. Absorption is dose-dependent and can be saturated.
Metabolism
Metabolized in the liver to thiamine pyrophosphate (TPP), the active coenzyme, and other metabolites.
Side Effects
Contraindications
- •Hypersensitivity to thiamine or any components of the formulation.
Drug Interactions
Alcohol
Can decrease thiamine absorption and increase excretion.
Furosemide
High doses may increase urinary excretion of thiamine.
Fluorouracil
Can inhibit thiamine phosphorylation, leading to functional deficiency.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Thiamine is water-soluble and generally considered non-toxic even at high doses as excess is excreted. Severe overdose is rare but could potentially cause allergic reactions (e.g., anaphylaxis with IV administration).
Pregnancy & Lactation
Generally considered safe at recommended daily allowances. Higher doses should be used with caution and under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to packaging for exact expiry.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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