Vitaplex
Generic Name
Pyridoxine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vitaplex 5 mg tablet | ৳ 0.51 | N/A |
Description
Overview of the medicine
Pyridoxine (Vitamin B6) is a water-soluble vitamin essential for various metabolic processes. It plays a crucial role in amino acid metabolism, neurotransmitter synthesis, and red blood cell formation.
Uses & Indications
Dosage
Adults
Typically 5-10 mg daily for deficiency, up to 100-200 mg daily for drug-induced neuropathy or certain conditions under medical supervision.
Elderly
Similar to adult dosage, dose adjustments may be needed based on renal function.
Renal_impairment
No specific adjustments usually required for mild to moderate impairment, but caution with high doses in severe impairment.
How to Take
Orally, with or without food.
Mechanism of Action
Pyridoxine acts as a coenzyme in numerous enzymatic reactions, particularly in amino acid and glycogen metabolism. It is converted to its active forms, pyridoxal phosphate (PLP) and pyridoxamine phosphate (PMP), which are involved in over 100 enzyme reactions, mainly deamination, decarboxylation, transamination, and racemization.
Pharmacokinetics
Onset
Effects are gradual, related to correction of deficiency.
Excretion
Excreted in the urine, primarily as 4-pyridoxic acid, an inactive metabolite.
Half life
Approximately 15-20 days for total body stores; plasma half-life of PLP is about 0.5-3 hours.
Absorption
Readily absorbed from the gastrointestinal tract, primarily in the jejunum.
Metabolism
Primarily metabolized in the liver to pyridoxal phosphate (PLP) and other active metabolites.
Side Effects
Contraindications
- •Hypersensitivity to Pyridoxine or any component of the formulation.
- •Rarely, severe peripheral neuropathy with very high doses over prolonged periods.
Drug Interactions
Levodopa
Pyridoxine can decrease the effectiveness of levodopa (without carbidopa/benserazide) by increasing its peripheral metabolism.
Isoniazid, Hydralazine, Penicillamine, Oral contraceptives
These drugs can increase pyridoxine requirements or interfere with its metabolism, leading to deficiency.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe peripheral neuropathy, ataxia, and sensory deficits. Management is supportive, including discontinuation of the drug and symptomatic treatment.
Pregnancy & Lactation
Generally considered safe at recommended daily allowances. High doses should be avoided during pregnancy and lactation unless clearly indicated by a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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