Vitigol
Generic Name
Vitigo
Manufacturer
Dermacare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vitigo 15 cream | ৳ 2,200.00 | N/A |
Description
Overview of the medicine
Vitigo is an oral medication indicated for the treatment of non-segmental vitiligo in adult and adolescent patients.
Uses & Indications
Dosage
Adults
10 mg orally once daily. May be increased to 20 mg once daily based on response and tolerability.
Elderly
No specific dose adjustment required, but monitor for adverse effects.
Renal_impairment
For moderate renal impairment, reduce dose to 5 mg once daily. Not recommended for severe renal impairment.
How to Take
Take orally with or without food. Swallow whole, do not crush or chew.
Mechanism of Action
Vitigo works by selectively inhibiting the Janus Kinase (JAK) pathway, which is involved in the pathogenesis of vitiligo by mediating inflammatory responses that lead to melanocyte destruction.
Pharmacokinetics
Onset
Clinical effects (repigmentation) typically observed within 3-6 months.
Excretion
Mainly excreted via urine (60%) and feces (20%).
Half life
Approximately 6-8 hours.
Absorption
Rapidly absorbed with peak plasma concentrations achieved within 1-2 hours.
Metabolism
Primarily metabolized by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Vitigo or any of its components.
- Active serious infections (e.g., tuberculosis, severe fungal infections).
- Severe hepatic impairment.
Drug Interactions
Immunosuppressants (e.g., Cyclosporine)
Increased risk of immunosuppression; avoid concomitant use.
Strong CYP3A4 Inducers (e.g., Rifampin)
May decrease Vitigo exposure; avoid concomitant use.
Strong CYP3A4 Inhibitors (e.g., Ketoconazole)
May increase Vitigo exposure; reduce Vitigo dose.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Management of overdose should include general supportive measures and monitoring of vital signs. Hemodialysis may not be effective in removing Vitigo.
Pregnancy & Lactation
Not recommended during pregnancy due to potential fetal harm. Women of childbearing potential should use effective contraception. Avoid breastfeeding during treatment and for at least 28 days after the last dose.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 years from manufacturing date
Availability
Pharmacies
Approval Status
Approved by DGDA
Patent Status
Under Patent
Clinical Trials
Phase 3 clinical trials demonstrated significant repigmentation in patients with non-segmental vitiligo compared to placebo.
Lab Monitoring
- Complete Blood Count (CBC) at baseline, 4 weeks, and then every 3 months.
- Liver Function Tests (LFTs) at baseline and periodically thereafter.
- Lipid Panel at baseline, 12 weeks, and then every 6 months.
Doctor Notes
- Assess patients for tuberculosis and viral hepatitis prior to initiating Vitigo.
- Monitor complete blood count and liver function tests regularly.
- Advise patients on the importance of sun protection.
Patient Guidelines
- Take Vitigo exactly as prescribed by your doctor.
- Do not stop taking Vitigo without consulting your doctor.
- Report any signs of infection (fever, chills) or unusual bruising/bleeding to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Vitigo may cause dizziness in some patients. If you experience dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain good hygiene to reduce infection risk.
- Protect skin from sun exposure, especially repigmenting areas.
- Manage stress, as it can sometimes exacerbate vitiligo.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.