Vitrocin
Generic Name
Vitrocin
Manufacturer
Vitara Healthcare (Example)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vitrocin 100 mg capsule | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Vitrocin is a macrolide antibiotic used to treat a wide range of bacterial infections including respiratory tract, skin, and sexually transmitted infections.
Uses & Indications
Dosage
Adults
Oral: 250-500 mg every 6-12 hours, depending on the severity of infection. Duration usually 7-14 days.
Elderly
No specific dose adjustment for elderly patients with normal renal and hepatic function.
Renal_impairment
No dose adjustment needed for mild to moderate renal impairment. For severe impairment (CrCl <10 mL/min), consider 50-75% of normal dose.
How to Take
Oral tablets/suspension can be taken with or without food. However, for better absorption, some forms are best taken on an empty stomach 1 hour before or 2 hours after meals. IV administration should be slow infusion.
Mechanism of Action
It inhibits bacterial protein synthesis by binding reversibly to the 50S ribosomal subunit of susceptible microorganisms.
Pharmacokinetics
Onset
Onset of action within 1-4 hours.
Excretion
Mainly excreted in bile; a small amount is excreted in urine.
Half life
Approximately 1.5 to 2 hours.
Absorption
Variable absorption, improved by enteric coating or ester forms. Bioavailability is around 30-65%.
Metabolism
Primarily hepatic via CYP3A4 enzyme system.
Side Effects
Contraindications
- Hypersensitivity to Vitrocin or any other macrolide antibiotics.
- Co-administration with cisapride, pimozide, ergotamine, dihydroergotamine due to risk of life-threatening arrhythmias.
- History of cholestatic jaundice/hepatic dysfunction associated with Vitrocin use.
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Theophylline, Carbamazepine, Digoxin
Increased levels of these drugs, monitor concentrations.
Statins (e.g., Simvastatin, Lovastatin)
Increased risk of myopathy/rhabdomyolysis.
CYP3A4 inhibitors (e.g., Azole antifungals, Protease inhibitors)
Increased Vitrocin levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, abdominal cramps, and diarrhea. Management includes gastric lavage, activated charcoal, and symptomatic supportive care. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe, but use only if clearly needed. Excreted in breast milk in small amounts; generally compatible with breastfeeding, but monitor infant for GI side effects.
Side Effects
Contraindications
- Hypersensitivity to Vitrocin or any other macrolide antibiotics.
- Co-administration with cisapride, pimozide, ergotamine, dihydroergotamine due to risk of life-threatening arrhythmias.
- History of cholestatic jaundice/hepatic dysfunction associated with Vitrocin use.
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Theophylline, Carbamazepine, Digoxin
Increased levels of these drugs, monitor concentrations.
Statins (e.g., Simvastatin, Lovastatin)
Increased risk of myopathy/rhabdomyolysis.
CYP3A4 inhibitors (e.g., Azole antifungals, Protease inhibitors)
Increased Vitrocin levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, abdominal cramps, and diarrhea. Management includes gastric lavage, activated charcoal, and symptomatic supportive care. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe, but use only if clearly needed. Excreted in breast milk in small amounts; generally compatible with breastfeeding, but monitor infant for GI side effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA, DGDA and other regulatory bodies
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Erythromycin has been extensively studied since its discovery in 1952, with numerous clinical trials establishing its efficacy and safety profile for various bacterial infections.
Lab Monitoring
- Liver function tests (LFTs) if therapy is prolonged or in patients with pre-existing hepatic impairment.
- Renal function tests (blood urea nitrogen, creatinine) if long-term use in patients with renal impairment.
- Electrolytes (potassium, magnesium) if there's a risk of QT prolongation.
Doctor Notes
- Advise patients to complete the entire course of therapy to prevent recurrence and resistance.
- Be mindful of potential drug interactions, especially with CYP3A4 substrates.
- Consider liver function tests for prolonged treatment or in patients with hepatic impairment.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Do not share this medicine with others.
- Inform your doctor about all other medications you are taking.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Vitrocin may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain good hydration throughout the treatment.
- Avoid alcohol consumption, especially if you have liver concerns.
- Practice good hygiene to prevent spread of infections.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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