Vivanta
Generic Name
Betahistine Dihydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vivanta 24 mg tablet | ৳ 45.00 | ৳ 450.00 |
Description
Overview of the medicine
Vivanta 24 mg Tablet contains Betahistine, primarily used for treating symptoms of Meniere's disease such as vertigo, tinnitus, and hearing loss. It works by improving blood flow to the inner ear.
Uses & Indications
Dosage
Adults
Initially 8 mg three times daily, or 16 mg two or three times daily, adjusted according to response. Max 48 mg/day. Vivanta 24 mg tablet is typically taken one tablet twice daily.
Elderly
No specific dosage adjustment required for elderly patients.
Renal_impairment
No specific dosage adjustment recommended for patients with renal impairment.
How to Take
Oral administration. Tablets should be swallowed whole with water, preferably with meals to minimize gastrointestinal discomfort.
Mechanism of Action
Betahistine acts as a weak H1-receptor agonist and a potent H3-receptor antagonist. It is thought to improve microcirculation in the inner ear by relaxing the precapillary sphincters, thereby reducing endolymphatic pressure and improving blood flow.
Pharmacokinetics
Onset
Symptoms may improve within days, but full effect often takes several weeks.
Excretion
Primarily excreted via the kidneys as metabolites within 24 hours.
Half life
Approximately 3.4 hours.
Absorption
Rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are reached within one hour.
Metabolism
Rapidly and extensively metabolized to 2-pyridylacetic acid (2-PAA), which is the primary inactive metabolite.
Side Effects
Contraindications
- Hypersensitivity to betahistine or any component of the formulation
- Phaeochromocytoma
Drug Interactions
Antihistamines
May reduce the effect of betahistine due to antagonistic effects.
MAO inhibitors
MAO inhibitors may increase the effect of betahistine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, somnolence, and convulsions at very high doses. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Limited data on use in pregnancy; generally not recommended unless clearly necessary. It is not known if betahistine is excreted in human milk; use with caution in breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to betahistine or any component of the formulation
- Phaeochromocytoma
Drug Interactions
Antihistamines
May reduce the effect of betahistine due to antagonistic effects.
MAO inhibitors
MAO inhibitors may increase the effect of betahistine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, somnolence, and convulsions at very high doses. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Limited data on use in pregnancy; generally not recommended unless clearly necessary. It is not known if betahistine is excreted in human milk; use with caution in breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available, original patent expired
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Betahistine in Meniere's disease and vertigo. Studies show it reduces the frequency and severity of vertigo attacks.
Lab Monitoring
- No specific routine lab monitoring required.
Doctor Notes
- Advise patients about the slow onset of action.
- Caution in patients with bronchial asthma or history of peptic ulcer.
- Monitor for symptom improvement and adjust dose accordingly.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking without consulting your doctor.
- Report any severe side effects immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
Betahistine is not expected to affect the ability to drive or operate machinery, but patients suffering from Meniere's disease or vertigo should be aware that the disease itself may impair their ability.
Lifestyle Advice
- Avoid activities that worsen vertigo.
- Maintain a low-salt diet if advised by your doctor for Meniere's disease.
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